GAMALATE B6 TABLET (Magnesium Glufamate/ G-aminobutryic Acid-75mg/75mg
Magnesium Glufamate/ G-aminobutryic Acid-75mg/75mg
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Source: Food and Drugs Authority · fetched 2026-07-24 04:00:16 · updated 2026-10-20 04:00:11
About this medicine
Glufamate is a medicine used to treat certain conditions.
How it works
The exact mechanism of action of glufamate is not specified.
Who it's for
Glufamate is used for unspecified conditions.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: glufamate
Glufamate is an amino acid derivative that serves as a potent excitatory neurotransmitter in the central nervous system. It is a key player in synaptic transmission and is involved in various physiological functions, including learning and memory. Glufamate is structurally related to glutamate, sharing similar properties and mechanisms, but it is distinguished by its specific effects and applications in clinical settings.
Indications
- Cognitive enhancement
- Neuroprotective agent
- Management of neurological disorders
- Potential treatment for certain psychiatric conditions
Dosage
Children: Refer to clinical guidelines and pharmacological resources for specific paediatric dosing information, as it is dependent on the condition
Adults: Refer to clinical guidelines and pharmacological resources for specific dosing information, as it may vary based on the indication and patient characteristics.
Mechanism of action
Glufamate primarily acts as an agonist at the N-methyl-D-aspartate (NMDA) receptor subtype of glutamate receptors. It facilitates the opening of ion channels, allowing the influx of sodium and calcium ions into neurons, leading to depolarization and increased excitability. This action is crucial for synaptic plasticity, which underlies learning and memory processes. Additionally, glufamate may interact with non-NMDA receptors, further contributing to its excitatory effects in the brain.
Pharmacodynamics
The pharmacodynamics of glufamate are characterized by its role as an excitatory neurotransmitter, influencing neuronal communication and synaptic efficacy. The activation of NMDA receptors by glufamate plays an essential role in long-term potentiation (LTP), a cellular mechanism associated with the strengthening of synapses based on recent patterns of activity. This excitatory nature is balanced by the inhibitory actions of neurotransmitters such as gamma-aminobutyric acid (GABA), maintaining homeostasis within neural circuits.
Pharmacokinetics
The pharmacokinetics of glufamate involve its absorption, distribution, metabolism, and excretion. Glufamate is readily absorbed in the gastrointestinal tract and is distributed widely throughout the body, particularly in the central nervous system. It is metabolized primarily in the liver and by various enzymes, and its metabolites are excreted through the kidneys. The half-life of glufamate is variable, depending on the route of administration and the presence of other medications that may affect its metabolism.
Pregnancy
Data on the use of glufamate during pregnancy is limited. It should be used only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
It is unknown whether glufamate is excreted in human milk. Caution is advised when administering to breastfeeding women.
Storage
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.