LONGDINE 60MG TABLETS (Each tablet contains Depoxeline HCL 60g)

Indications

• Depression
• Generalized anxiety disorder
• Panic disorder
• Obsessive-compulsive disorder
• Social anxiety disorder

Dosage

Children: Refer to the BNF for Children for appropriate paediatric dosing recommendations.

Adults: Refer to prescribing guidelines or a clinical pharmacist for specific adult dosages based on the condition being treated.

Mechanism of action

Depoxeline works by selectively inhibiting the reuptake of serotonin (5-HT) at the presynaptic neuronal membrane, leading to increased availability of serotonin at the synaptic cleft. This mechanism is believed to contribute to its antidepressant and anxiolytic effects.

Pharmacodynamics

The pharmacodynamic properties of depoxeline involve its action on serotonin receptors, predominantly the 5-HT1A receptor. By increasing serotonergic neurotransmission, depoxeline can alleviate symptoms of depression and anxiety. Its effects may also extend to influencing other neurotransmitter systems, which can enhance its therapeutic profile in mood regulation.

Pharmacokinetics

Depoxeline is absorbed following oral administration, with peak plasma concentrations occurring within a few hours. It undergoes hepatic metabolism, primarily via cytochrome P450 enzymes, and has a variable half-life depending on individual metabolic rates. The drug is excreted mainly in the urine, with a combination of unchanged drug and metabolites.

Contra-indications

• Hypersensitivity to depoxiline or any of its components
• Severe liver impairment
• Severe renal impairment
• Concurrent use of monoamine oxidase inhibitors (MAOIs)

Adverse effects

• Nausea
• Dizziness
• Drowsiness
• Dry mouth
• Constipation
• Fatigue
• Increased sweating
• Headache

Interactions

• Caution with other CNS depressants, which may enhance sedative effects
• Increased risk of serotonin syndrome when combined with other serotonergic drugs
• Potential interaction with antihypertensive medications

Precautions

• Use with caution in patients with a history of seizures
• Monitor for signs of serotonin syndrome, especially when combined with other medications affecting serotonin levels
• Assess liver and renal function before initiation

Pregnancy

There is limited data on the use of depoxiline in pregnant women. Use only if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

It is unknown whether depoxiline is excreted in human milk. Caution should be exercised when administering to nursing mothers.

Storage

Store at room temperature, away from moisture and heat. Keep out of reach of children.

Formulations

• Oral tablets
• Oral capsules