LOSHAL 50 TABLETS (Each tablet contains Lorsatan Potassium 50mg)
Lorsatan Potassium
What it does
Lorsatan is a medication that helps lower blood pressure and protect kidney function.
Commonly used for: high blood pressure (hypertension), heart failure, kidney problems in diabetes
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Food and Drugs Authority · fetched 2026-04-18 08:32:59 · updated 2026-10-20 04:00:05
About this medicine
Lorsatan is a medication that helps lower blood pressure and protect kidney function.
What it treats
- high blood pressure (hypertension)
- heart failure
- kidney problems in diabetes
How it works
Lorsatan works by relaxing blood vessels, making it easier for the heart to pump blood.
Who it's for
It is for adults and sometimes for children who need help managing high blood pressure or specific heart and kidney conditions.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: lorsatan
Losartan is an angiotensin II receptor blocker (ARB) used primarily in the treatment of hypertension and to protect the kidneys in patients with type 2 diabetes. It works by inhibiting the action of angiotensin II, a potent vasoconstrictor, leading to vasodilation, reduced blood pressure, and decreased workload on the heart.
Indications
- Hypertension
- Heart failure
- Diabetic nephropathy
- Left ventricular hypertrophy
- Chronic kidney disease
Dosage
Children: Refer to the BNF for Children for appropriate dosing information.
Adults: Refer to established guidelines for specific dosing based on individual patient needs and clinical conditions.
Mechanism of action
Losartan selectively blocks the binding of angiotensin II to the AT1 receptor, which is responsible for the vasoconstrictor effects of angiotensin II. This blockade results in vasodilation, reduced secretion of aldosterone, decreased reabsorption of sodium, and an overall reduction in blood pressure. Additionally, losartan has been shown to increase plasma renin activity and angiotensin II levels, which may contribute to its therapeutic effects.
Pharmacodynamics
Losartan reduces blood pressure through its antihypertensive effects, which include vasodilation and decreased peripheral vascular resistance. It has a long duration of action, allowing for once-daily dosing in most cases. The pharmacodynamic effects also include favorable renal outcomes in patients with diabetic nephropathy.
Pharmacokinetics
Losartan is rapidly absorbed following oral administration, with peak plasma concentrations occurring within 1 to 2 hours. It undergoes extensive first-pass metabolism in the liver to form an active metabolite, E3174, which has a longer half-life and contributes to the drug's pharmacological effects. Losartan and its metabolite are both primarily eliminated via the kidneys and feces. The elimination half-life of losartan is approximately 2 hours, while that of E3174 is about 6 to 9 hours.
Contra-indications
- Hypersensitivity to losartan or any of its components
- Pregnancy
- Severe hepatic impairment
- Bilateral renal artery stenosis
Adverse effects
- Dizziness
- Fatigue
- Headache
- Hypotension
- Hyperkalemia
- Renal impairment
Interactions
- Potassium-sparing diuretics may increase the risk of hyperkalemia
- Non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the antihypertensive effect
- Lithium concentrations may increase when used with losartan
Precautions
- Monitor renal function regularly when initiating therapy
- Caution in patients with dehydration or volume depletion
- Assess electrolyte levels periodically, particularly potassium
Pregnancy
Losartan is contraindicated during pregnancy due to the risk of fetal harm.
Breast-feeding
Limited data, use with caution after assessing the risk-benefit ratio.
Storage
Store at room temperature, away from moisture and heat.
Formulations
- Tablets: 25 mg, 50 mg, 100 mg
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.