Montene 10 Tablets ( Each tablet contains Montalukast Sodium 10mg)
Montalukast Sodium
What it does
Montalukast is a medication used to help manage breathing problems and allergies.
Commonly used for: asthma, seasonal allergies (hay fever), chronic obstructive pulmonary disease (COPD)
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Source: Food and Drugs Authority · fetched 2026-05-22 02:34:30 · updated 2026-10-20 04:00:05
About this medicine
Montalukast is a medication used to help manage breathing problems and allergies.
What it treats
- asthma
- seasonal allergies (hay fever)
- chronic obstructive pulmonary disease (COPD)
How it works
It works by blocking substances in the body that cause inflammation and tightening of the airways.
Who it's for
This medicine is for people with asthma or allergies, including children and adults.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: montalukast
Montelukast is a leukotriene receptor antagonist used primarily for the management of asthma and allergic rhinitis. It works by blocking the action of leukotrienes, which are inflammatory mediators that contribute to bronchoconstriction, mucus production, and airway edema. By inhibiting leukotriene receptors, montelukast helps to reduce inflammation and improve respiratory function.
Indications
- Asthma
- Allergic rhinitis
- Exercise-induced bronchoconstriction
Dosage
Children: Refer to the BNF for Children for specific dosing recommendations.
Adults: Refer to the BNF for specific dosing recommendations.
Mechanism of action
Montelukast selectively inhibits the cysteinyl leukotriene receptor 1 (CysLT1), preventing the action of leukotrienes such as LTC4, LTD4, and LTE4. This blockade leads to reduced bronchoconstriction, decreased mucus secretion, and diminished inflammatory responses in the airways, ultimately improving symptoms associated with asthma and allergic rhinitis.
Pharmacodynamics
The pharmacodynamic effects of montelukast include bronchodilation, reduction of airway inflammation, and decreased mucus secretion. The onset of action is typically observed within hours of administration, with peak effects occurring within 24 hours. It is effective in both the prevention and treatment of asthma symptoms, as well as in alleviating allergic rhinitis symptoms.
Pharmacokinetics
Montelukast is well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring approximately 2 to 4 hours after oral administration. It is highly protein-bound (approximately 99%) and has a half-life of about 2.7 to 5.5 hours. The drug is extensively metabolized in the liver by cytochrome P450 enzymes, primarily CYP3A4 and CYP2C9, and is excreted mainly as metabolites in the urine and feces. Food does not significantly affect its absorption.
Contra-indications
- Hypersensitivity to montelukast or any of its components
Adverse effects
- Headache
- Gastrointestinal disturbances (nausea, diarrhea)
- Fatigue
- Dizziness
- Mood changes including agitation, aggression, anxiety, sleep disturbances
Interactions
- May interact with CYP450 inducers such as phenobarbital, rifampicin, and certain herbal supplements, potentially reducing montelukast efficacy
- Minimal interactions with other medications due to its specific metabolic pathway
Precautions
- Monitor for neuropsychiatric events in patients with a history of mood disorders
- Use caution in patients with hepatic impairment
Pregnancy
Montelukast is classified as pregnancy category B, indicating no evidence of risk in humans; however, it should only be used if clearly needed.
Breast-feeding
Montelukast is excreted in breast milk but is not expected to affect the nursing infant adversely; consult a healthcare provider for concerns.
Storage
Store at room temperature, away from moisture and heat. Keep out of reach of children.
Formulations
- Tablets (10 mg)
- Chewable tablets (4 mg, 5 mg)
- Granules (4 mg)
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.