QUAMFORT TABLETS
CLOMOPHENE CITRATE
What it does
Clomophene is a medicine that helps with fertility issues by stimulating the ovaries to release eggs.
Commonly used for: infertility (difficulty getting pregnant), anovulation (not ovulating)
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Food and Drugs Authority · fetched 2026-05-08 08:00:16 · updated 2026-10-20 04:00:04
About this medicine
Clomophene is a medicine that helps with fertility issues by stimulating the ovaries to release eggs.
What it treats
- infertility (difficulty getting pregnant)
- anovulation (not ovulating)
How it works
It works by encouraging the ovaries to produce and release eggs, which can help increase the chances of pregnancy.
Who it's for
This medicine is for women who have trouble ovulating and want to conceive.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: clomophene
Clomiphene is a selective estrogen receptor modulator (SERM) primarily used in the treatment of ovulatory dysfunction in women who are infertile. It acts by modulating estrogen receptors in the hypothalamus and pituitary gland, leading to increased gonadotropin release and subsequent stimulation of ovarian function. Clomiphene is commonly prescribed for conditions such as polycystic ovary syndrome (PCOS) and other forms of anovulation.
Indications
- Anovulation
- Infertility due to ovulatory dysfunction
- Polycystic ovary syndrome (PCOS)
Dosage
Children: Refer to BNF for Children for specific dosing recommendations.
Adults: Refer to BNF for specific dosing recommendations.
Mechanism of action
Clomiphene works by binding to estrogen receptors in the hypothalamus, blocking endogenous estrogen from exerting its negative feedback on gonadotropin-releasing hormone (GnRH) secretion. This results in increased levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), promoting ovarian follicular development and ovulation.
Pharmacodynamics
Clomiphene has a biphasic action depending on the dose and duration of treatment. At low doses, it acts as an estrogen agonist, while at higher doses, it exhibits antagonist properties. This dual action helps induce ovulation by promoting the secretion of FSH and LH. Additionally, clomiphene may enhance the sensitivity of ovarian follicles to gonadotropins and improve the likelihood of ovulation.
Pharmacokinetics
Clomiphene is well-absorbed from the gastrointestinal tract, with peak plasma concentrations occurring approximately 6 to 8 hours after oral administration. It has a long half-life, allowing for prolonged action, and is metabolized primarily in the liver. The drug is excreted in urine and feces, with a significant portion of the dose being eliminated as metabolites rather than unchanged drug.
Contra-indications
- Pregnancy
- Unexplained uterine bleeding
- Ovarian cysts (non-functional)
- Liver disease
- Active thrombophlebitis or thromboembolic disorders
Adverse effects
- Hot flashes
- Nausea
- Vomiting
- Abdominal discomfort
- Visual disturbances
- Ovarian enlargement
- Multiple pregnancies
Interactions
- Anticoagulants - may enhance effects of anticoagulants
- Thyroid hormones - may require adjustment of thyroid hormone doses
- Corticosteroids - may affect corticosteroid metabolism
Precautions
- Monitor liver function tests before and during treatment
- Use with caution in patients with a history of endometriosis
- Consider potential for multiple gestations
- Monitor for signs of ovarian hyperstimulation syndrome
Pregnancy
Clomiphene should not be used during pregnancy due to its potential teratogenic effects.
Breast-feeding
Clomiphene is not recommended during breastfeeding due to potential effects on milk production.
Storage
Store at room temperature, away from moisture and heat. Keep out of reach of children.
Formulations
- Tablets: 50 mg
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.