SCIRICA 75MG CAPSULES (Each capsule contains Pregabalim 75mg)
Pregabalim
What it does
Pregabalin is a medication used to help manage nerve pain and certain types of seizures.
Commonly used for: nerve pain (neuropathic pain), epilepsy (seizures), generalized anxiety disorder
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Food and Drugs Authority · fetched 2026-05-22 02:34:33 · updated 2026-10-20 04:00:05
About this medicine
Pregabalin is a medication used to help manage nerve pain and certain types of seizures.
What it treats
- nerve pain (neuropathic pain)
- epilepsy (seizures)
- generalized anxiety disorder
How it works
Pregabalin works by calming overactive nerves in the brain and body, which helps to reduce pain and prevent seizures.
Who it's for
Pregabalin is for adults dealing with nerve pain, seizures, or anxiety issues.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: pregabalim
Pregabalin is an anticonvulsant and analgesic agent, primarily used for the management of neuropathic pain, epilepsy, and generalized anxiety disorder. It is structurally related to the neurotransmitter gamma-aminobutyric acid (GABA), though it does not bind to GABA receptors. Pregabalin is indicated for various conditions involving nerve pain and seizure disorders.
Indications
- Neuropathic pain associated with diabetic peripheral neuropathy
- Postherpetic neuralgia
- Fibromyalgia
- Partial-onset seizures in adults with epilepsy
- Generalized anxiety disorder
Dosage
Children: Refer to the BNF for Children for specific dosing information.
Adults: Refer to the BNF for specific dosing information.
Mechanism of action
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This action inhibits excitatory neurotransmitter release, leading to a reduction in neuronal excitability and modulation of pain pathways.
Pharmacodynamics
Pregabalin exhibits analgesic and anticonvulsant properties. It is effective in reducing neuropathic pain by decreasing the release of several neurotransmitters, including glutamate, norepinephrine, and substance P. It has a rapid onset of action and its effects can be observed within a week of starting treatment.
Pharmacokinetics
Pregabalin is well absorbed after oral administration, with peak plasma concentrations typically reached within 1 hour. It has a bioavailability of approximately 90%, and food does not significantly affect its absorption. The drug is not extensively metabolized in the liver and is excreted unchanged in the urine. It has a half-life of about 6 hours, necessitating multiple daily doses for sustained effect.
Contra-indications
- Hypersensitivity to pregabalin or any of its components
- Severe renal impairment
Adverse effects
- Dizziness
- Somnolence
- Dry mouth
- Edema
- Weight gain
- Blurred vision
- Cognitive dysfunction
- Increased appetite
- Constipation
Interactions
- CNS depressants may enhance the sedative effects of pregabalin
- Pregabalin may increase the risk of respiratory depression when used with opioids
- Alcohol may increase adverse effects and should be used with caution
Precautions
- Monitor for signs of misuse, abuse, or dependence
- Caution in patients with a history of substance abuse
- Assess renal function prior to initiation and adjust dose accordingly
- Risk of suicidal thoughts or behavior has been observed
Pregnancy
Pregabalin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Animal studies have shown reproductive toxicity.
Breast-feeding
Pregabalin is excreted in breast milk, and caution should be exercised when administering to breastfeeding women.
Storage
Store at room temperature, away from moisture and heat. Keep out of reach of children.
Formulations
- Capsules
- Oral solution
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.