TELFAST TABLET 120
Fexofanadine hydrochloride
What it does
Fexofenadine is an antihistamine used to relieve allergy symptoms.
Commonly used for: hay fever (allergic rhinitis), hives (urticaria)
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Source: Food and Drugs Authority · fetched 2026-04-18 08:37:38 · updated 2026-07-31 04:00:07
About this medicine
Fexofenadine is an antihistamine used to relieve allergy symptoms.
What it treats
- hay fever (allergic rhinitis)
- hives (urticaria)
How it works
It works by blocking the effects of histamine, a substance in the body that causes allergic symptoms.
Who it's for
This medication is suitable for adults and children who suffer from allergy symptoms.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: fexofanadine
Fexofenadine is a second-generation antihistamine primarily used to relieve symptoms associated with allergic rhinitis and chronic urticaria. It is a selective antagonist of peripheral H1 receptors, which helps to mitigate allergy symptoms without the sedative effects commonly associated with first-generation antihistamines.
Indications
- Allergic rhinitis
- Seasonal allergic rhinitis
- Chronic idiopathic urticaria
Dosage
Children: Refer to the BNF for Children for specific dosing recommendations.
Adults: Refer to the BNF for specific dosing recommendations.
Mechanism of action
Fexofenadine works by selectively inhibiting the H1 histamine receptor, preventing histamine from binding to its receptor and thus reducing the effects of histamine such as vasodilation, increased vascular permeability, and sensory nerve stimulation. This mechanism leads to a decrease in allergy-related symptoms such as sneezing, itching, and runny nose.
Pharmacodynamics
Fexofenadine exhibits a rapid onset of action, typically within one hour of administration, and provides relief from allergy symptoms for up to 24 hours. It has minimal sedative effects due to its limited ability to cross the blood-brain barrier compared to first-generation antihistamines. The drug also has a long half-life, which supports once-daily dosing.
Pharmacokinetics
Fexofenadine is rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations occurring about 2 to 3 hours post-dose. It undergoes minimal metabolism, primarily excreted unchanged in the urine and feces. The drug's bioavailability is affected by the presence of food, especially high-fat meals, which can reduce absorption.
Adverse effects
- Headache
- Drowsiness
- Nausea
- Dry mouth
- Dizziness
- Fatigue
Interactions
- Antacids containing aluminum or magnesium may reduce the absorption and effectiveness of fexofenadine
- Erythromycin and ketoconazole can increase fexofenadine levels
Precautions
- Caution in patients with renal impairment
- Use with caution in elderly patients
Pregnancy
Fexofenadine is classified as Category C, meaning that risks cannot be ruled out. Consult a healthcare professional before use.
Breast-feeding
It is not known whether fexofenadine is excreted in human milk. Caution is advised when administering to breastfeeding women.
Storage
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
Formulations
- Tablets
- Oral suspension
- Extended-release tablets
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.