THYROPACE FILM COATED TABLETS

Indications

• Depression
• Stress reduction
• Cognitive enhancement
• Chronic fatigue
• Narcolepsy

Dosage

Children: Refer to the BNF for Children for recommended dosages in paediatric patients.

Adults: Refer to the BNF for specific dosing information, as it varies based on condition and formulation.

Mechanism of action

Tyrosine is produced in cells by hydroxylating phenylalanine. Its antidepressant activity is attributed to its role as a precursor in the synthesis of norepinephrine and dopamine. Elevated levels of these neurotransmitters are believed to contribute to its antidepressant effects.

Pharmacodynamics

L-Tyrosine is critical for synthesizing neurotransmitters, proteins, and enzymes. It can elevate mood, improve cognitive functions, and reduce stress. Its involvement in thyroid hormone production links it to metabolic processes, while deficiencies can manifest in various physiological symptoms, including low blood pressure and body temperature.

Pharmacokinetics

L-Tyrosine is readily absorbed from the gastrointestinal tract. Its metabolism involves conversion to catecholamines via the enzyme tyrosine hydroxylase. It is distributed throughout the body and utilized in protein synthesis as well as neurotransmitter production. The half-life and specific elimination pathways are not well-defined in the provided data.

Adverse effects

• Gastrointestinal disturbances
• Nausea
• Headaches
• Fatigue
• Heartburn

Precautions

• Caution in patients with hyperthyroidism
• Use with caution in patients taking medications for depression

Pregnancy

Limited information is available regarding the safety of L-tyrosine during pregnancy. It is advisable to consult a healthcare professional before use.

Breast-feeding

Limited information is available regarding the safety of L-tyrosine during breastfeeding. Consultation with a healthcare professional is recommended.

Storage

Store in a cool, dry place away from direct sunlight. Keep out of reach of children.

Mechanism of action

Tyrosine is produced in cells by hydroxylating the essential amino acid phenylalanine. This relationship is much like that between cysteine and methionine. Half of the phenylalanine required goes into the production of tyrosine; if the diet is rich in tyrosine itself, the requirements for phenylalanine are reduced by about 50%. The mechanism of L-tyrosine's antidepressant activity can be accounted for by the precursor role of L-tyrosine in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be associated with antidepressant effects.

Pharmacodynamics

Tyrosine is a nonessential amino acid synthesized in the body from phenylalanine. Tyrosine is critical for the production of the body's proteins, enzymes and muscle tissue. Tyrosine is a precursor to the neurotransmitters norepinephrine and dopamine. It can act as a mood elevator and an anti-depressant. It may improve memory and increase mental alertness. Tyrosine aids in the production of melanin and plays a critical role in the production of thyroxin (thyroid hormones). Tyrosine deficiencies are manifested by hypothyroidism, low blood pressure and low body temperature. Supplemental tyrosine has been used to reduce stress and combat narcolepsy and chronic fatigue.