GLOVATE CREAM

Indications

• Psoriasis
• Eczema (atopic dermatitis)
• Contact dermatitis
• Seborrheic dermatitis
• Lichen planus
• Nummular dermatitis

Dosage

Children: Refer to the BNF for Children for specific dosing recommendations based on age, weight, and condition.

Adults: Refer to the BNF for specific dosing recommendations depending on the condition being treated and patient factors.

Mechanism of action

Clobetasole exerts its effects by binding to glucocorticoid receptors in the cytoplasm of target cells. This complex then translocates to the nucleus, where it influences the transcription of specific genes, leading to the inhibition of pro-inflammatory cytokines and the promotion of anti-inflammatory proteins. This mechanism results in decreased inflammation, immune response, and subsequent symptom relief.

Pharmacodynamics

Clobetasole has potent anti-inflammatory, antipruritic, and vasoconstrictive effects. Its potency allows it to effectively reduce the signs and symptoms of skin inflammation. The drug's actions are mediated through its interaction with the corticosteroid receptors that modify gene expression, leading to a decrease in the synthesis of inflammatory mediators such as prostaglandins and leukotrienes.

Pharmacokinetics

Clobetasole is well-absorbed when applied topically, with systemic absorption being influenced by factors such as skin integrity, the vehicle used, and the area of application. Once absorbed, it undergoes hepatic metabolism, and its metabolites are excreted primarily via urine. The half-life of clobetasole in the system is variable, and prolonged use can lead to increased systemic absorption, which may cause adrenal suppression.

Contra-indications

• Hypersensitivity to clobetasol or any of the excipients
• Untreated bacterial, viral, or fungal infections of the skin
• Perioral dermatitis
• Rosacea

Adverse effects

• Skin atrophy
• Telangiectasia
• Striae
• Acneiform eruptions
• Systemic absorption leading to adrenal suppression
• Hypopigmentation
• Burning, itching, or irritation at the application site

Interactions

• Potential interaction with other topical corticosteroids leading to increased risk of systemic side effects
• Concurrent use of occlusive dressings may increase systemic absorption

Precautions

• Use with caution in patients with a history of hypersensitivity to corticosteroids
• Long-term use should be monitored for signs of adrenal suppression
• Not for use on the face, groin, or armpits unless directed by a healthcare professional
• Avoid contact with eyes

Pregnancy

Clobetasol is classified as a Category C medication. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

Clobetasol is excreted in human milk. Caution should be exercised when administering to nursing mothers, particularly if applied to the breast area.

Storage

Store at room temperature, away from moisture and heat. Keep out of reach of children.

Formulations

• Topical cream
• Topical ointment
• Topical lotion
• Topical gel