Imatinib Mesylate
Imatinib mesylate 400 mg,Isopropyl Alcohol q.s ml,Magnesium Stearate 1.60 mg/6 mL,Opadry Brown 02F86982 9.60 mg/6 mL,Povidone K-30 0.40 mg/6 mL
What it does
Alcohol is a substance that can affect your mood and behavior. It is important to use it carefully, especially if you are taking other medications.
Commonly used for: social enjoyment, anxiety relief, temporary relaxation
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Answers come only from this medicine's registration record, BNF monograph and interaction data - not medical advice.
Medicine sourcing is available in Kenya only. We don't sell or dispense medicines - licensed pharmacies do.
Sourcing - Kenya onlyRegistration & product details
Source: Tanzania Medicines and Medical Devices Authority · fetched 2026-08-06 03:00:38 · updated 2026-09-17 03:00:43
Drug Interactions
156Pharmacodynamic Warnings
Alcohol appears in TABLE 1: Drugs that cause hepatotoxicity
Imatinib appears in TABLE 4: Drugs with antiplatelet effects
Alcohol appears in TABLE 8: Drugs that cause hypotension
Alcohol appears in TABLE 11: Drugs with CNS depressant effects
Imatinib appears in TABLE 15: Drugs that cause myelosuppression
Severe (2)
Antipsychotics, Second Generation - increases exposure
Imatinib is predicted to increase the exposure to antipsychotics, second generation (cariprazine). Avoid.
Imatinib - decreases exposure
Antiepileptics (carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone) are predicted to decrease the exposure to imatinib. Avoid.
Moderate (34)
Alfentanil - increases exposure
Imatinib is predicted to increase the exposure to opioids (alfentanil, buprenorphine, fentanyl, oxycodone). Monitor and adjust dose.
Amlodipine - increases exposure
Imatinib is predicted to increase the exposure to calcium channel blockers (amlodipine, felodipine, lacidipine, lercanidipine, nicardipine, nifedipine, nimodipine). Monitor and adjust dose.
Atorvastatin - increases exposure
Imatinib is predicted to increase the exposure to statins (atorvastatin). Monitor and adjust dose.
Bosutinib - increases exposure
Imatinib is predicted to increase the exposure to bosutinib. Avoid or adjust dose. Also see TABLE 15 p. 1520 → Also see TABLE 4 p. 1517.
Buprenorphine - increases exposure
Imatinib is predicted to increase the exposure to opioids (alfentanil, buprenorphine, fentanyl, oxycodone). Monitor and adjust dose.
Unknown (120)
Abemaciclib - increases exposure
Imatinib is predicted to increase the exposure to abemaciclib.
Acalabrutinib - increases exposure
Imatinib is predicted to increase the exposure to a calabrutinib. Avoid or monitor. Also see TABLE 4 p. 1517.
Acitretin - increases concentration
Alcohol potentially increases the concentration of retinoids (acitretin). Avoid and for 2 months after stopping acitretin.
Alphablockers - increases exposure
Imatinibispredictedtoincreasetheexposuretoalphablockers (tamsulosin).oTheoretical
Alprazolam - increases exposure
Imatinib is predicted to increase the exposure to alprazolam.
Data from BNF 85 (British National Formulary). This is not a substitute for professional medical advice. Matched via: exact
About alcohol
Alcohol is a substance that can affect your mood and behavior. It is important to use it carefully, especially if you are taking other medications.
What it treats
- social enjoyment
- anxiety relief
- temporary relaxation
How it works
Alcohol affects the brain and central nervous system, leading to changes in mood and behavior.
Who it's for
Adults who consume alcohol in moderation for social or relaxation purposes.
Cautions
- • Be cautious if taking medications that can harm the liver.
- • Use with care if you have low blood pressure.
- • Avoid combining with medications that can cause drowsiness.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
About brown
Brown is a medication used to treat various health conditions. It is important to use it as directed by a healthcare professional.
What it treats
- general health improvement
- specific medical conditions
How it works
Brown works by affecting certain processes in the body to help manage or alleviate symptoms of the conditions it is prescribed for.
Who it's for
Brown is intended for patients who have been prescribed this medication by their healthcare provider.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
About imatinib
Imatinib is a medication used to treat certain types of cancer by blocking specific signals that allow cancer cells to grow.
What it treats
- chronic myeloid leukaemia (CML)
- gastrointestinal stromal tumors (GIST)
- other cancers as determined by a doctor
How it works
Imatinib works by targeting specific proteins in cancer cells, preventing them from growing and dividing.
Who it's for
Imatinib is for adults and children diagnosed with certain types of cancer, particularly CML and GIST.
Cautions
- • Be cautious if taking other medications that prevent blood clotting.
- • Use with care if taking drugs that can affect blood cell production.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
About isopropyl
Isopropyl is commonly used in various topical applications for its antiseptic properties.
What it treats
- skin disinfectant
- cleaning agent
- antiseptic for minor cuts and scrapes
How it works
Isopropyl works by killing bacteria and preventing infection when applied to the skin.
Who it's for
It is suitable for anyone needing a disinfectant for minor skin issues.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
About opadry
Opadry is a coating agent used in pharmaceutical formulations.
What it treats
- to improve the taste of medicines
- to protect the active ingredients in tablets and capsules
How it works
Opadry forms a protective layer around tablets and capsules, which helps to mask their taste and protect the ingredients from moisture and light.
Who it's for
Opadry is suitable for various patients who are taking medications in tablet or capsule form.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
About povidone
Povidone is a synthetic polymer often used as a disinfectant and to help deliver medications in various forms.
What it treats
- skin infections
- wound care
- eye infections (conjunctivitis)
How it works
Povidone works by killing bacteria and other germs, helping to prevent infections.
Who it's for
Povidone is suitable for people needing treatment for skin or eye infections.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: Imatinib
BNF-referencedImatinib is a targeted therapy and a protein-tyrosine kinase inhibitor, primarily used in the treatment of certain types of cancer such as chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GISTs). It works by inhibiting the BCR-ABL fusion protein, which is involved in the pathogenesis of CML, and also targets other receptor tyrosine kinases. This medication has transformed the management of these malignancies, providing significant improvements in patient outcomes.
Indications
- Chronic myeloid leukemia (CML) in chronic phase
- Chronic myeloid leukemia (CML) in accelerated phase
- Chronic myeloid leukemia (CML) in blast crisis
Mechanism of action
Imatinib mesylate functions as a protein-tyrosine kinase inhibitor by binding to the ATP pocket of the BCR-ABL tyrosine kinase, which is constitutively active due to the Philadelphia chromosome abnormality found in chronic myeloid leukemia. This binding prevents the phosphorylation of downstream proteins involved in cell proliferation and survival. Additionally, imatinib inhibits other receptor tyrosine kinases such as those for platelet-derived growth factor (PDGF) and stem cell factor (SCF), further contributing to its anti-cancer effects.
Pharmacodynamics
Imatinib is a selective inhibitor of the BCR-ABL fusion protein, affecting several downstream signaling pathways associated with cancer cell growth, including the Ras/MapK pathway for cellular proliferation, and the PI3K/AKT/BCL-2 pathway involved in apoptosis. While it inhibits multiple tyrosine kinases, its selectivity for BCR-ABL makes it particularly effective against cancers that rely heavily on this signaling pathway for survival and proliferation.
Pharmacokinetics
Imatinib is well absorbed following oral administration, with peak plasma concentrations typically occurring within 2 to 4 hours. It has a volume of distribution of approximately 300 L, indicating extensive tissue distribution. The drug is primarily metabolized by the liver, predominantly via cytochrome P450 enzymes, particularly CYP3A4. The elimination half-life is about 18 hours, allowing for once-daily dosing in most cases. The drug is excreted mainly via the bile, with a small percentage eliminated unchanged in the urine.
Contra-indications
- Hypersensitivity to imatinib or any of its excipients
- Active infection
- Severe hepatic impairment
Adverse effects
- Alopecia
- Anaemia
- Appetite loss
- Bone marrow disorders
- Chills
- Constipation
- Cough
- Diarrhoea
- Dizziness
- Dry eye
- Dyspnoea
- Excessive tearing
- Eye inflammation
- Fever
- Fluid imbalance
- Flushing
- Gastrointestinal discomfort
- Gastrointestinal disorders
- Hemorrhage
- Headaches
- Insomnia
- Joint disorders
- Muscle complaints
- Nausea
- Rash
- Neutropenia
- Pneumonitis
Interactions
- Antiepileptics (carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone) may decrease exposure to imatinib (severe interaction)
- Antipsychotics (second-generation) may increase exposure to imatinib (severe interaction)
- Propafenone may increase exposure to imatinib (moderate interaction)
- Midazolam may increase exposure to imatinib (moderate interaction)
- Bosutinib may increase exposure to imatinib (moderate interaction)
- Buspirone may increase exposure to imatinib (moderate interaction)
- Calcium channel blockers may increase exposure to imatinib (moderate interaction)
- Amlodipine may increase exposure to imatinib (moderate interaction)
- Felodipine may increase exposure to imatinib (moderate interaction)
- Lacidipine may increase exposure to imatinib (moderate interaction)
Precautions
- Monitor for signs and symptoms of active infection during treatment
- Avoid in patients with active hepatitis
- Use with caution in patients with severe hepatic impairment
- Regular monitoring of blood counts is recommended due to the risk of bone marrow suppression
Pregnancy
Manufacturer advises avoidance of use during pregnancy
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Clinical monograph: Alcohol
BNF-referencedAlcohol is a volatile, flammable liquid used primarily as an antiseptic for skin disinfection and preparation before injections. It is commonly employed in medical settings to cleanse the skin and reduce the risk of infection.
Indications
- Skin disinfection
- Preparation of skin before injections
- Cleansing minor wounds
Dosage
Children: Apply to the skin as required; consult product literature for specific guidance.
Adults: Apply to the skin as required for disinfection.
Mechanism of action
Alcohol exerts its antiseptic effect by denaturing proteins, disrupting cell membranes, and dehydrating microbial cells, leading to cell lysis and death.
Pharmacodynamics
Alcohol has broad-spectrum antimicrobial activity, effective against bacteria, fungi, and viruses. Its efficacy is influenced by concentration, with higher concentrations generally being more effective.
Pharmacokinetics
Alcohol is rapidly absorbed through the skin and mucous membranes. It is metabolized primarily in the liver, with a half-life that varies based on the individual's metabolic rate and the amount consumed.
Contra-indications
- Concomitant use with lithium
- Regular use in neonates
- Patients with severe burns when diathermy has been preceded by application of alcoholic skin disinfectants
Adverse effects
- Eye erythema
- Punctate keratitis
- Cytotoxicity
- Eye discolouration
Interactions
- Increases risk of visual disturbances with antiepileptics
- Increases concentration with methylphenidate
- Increases risk of facial flushing and skin irritation with topical pimecrolimus
- Increases concentration with retinoids
- Increases concentration with acitretin
- Increases risk of facial flushing and skin irritation with topical tacrolimus
- Decreases antidiuretic effect with vasopressin
Precautions
- Avoid regular application to inflamed or broken skin or mucosa
- Avoid broken skin
- Flammable
Pregnancy
Sufficient iodine may be absorbed to affect the fetal thyroid in the second and third trimester.
Breast-feeding
Avoid regular or excessive use.
Storage
Store in a cool, dry place away from heat and direct sunlight.
Formulations
- Betadine 2.5% dry powder spray
- Industrial methylated spirit
- Povidone-Iodine 25 mg per 1 gram
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Clinical monograph: brown
Brown is not a recognized pharmacological agent; however, if referring to a color-coded classification of a drug or a specific medication associated with a brown appearance, clarification is needed. In pharmacology, colors can sometimes indicate the formulation or specific properties of a medication, but further details are required for a comprehensive overview.
Dosage
Children: Refer to specific product information for dosing guidelines.
Adults: Refer to specific product information for dosing guidelines.
Pregnancy
Consult healthcare provider for specific information regarding use during pregnancy.
Breast-feeding
Consult healthcare provider for specific information regarding use during breastfeeding.
Storage
Store in a cool, dry place away from direct sunlight.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Clinical monograph: isopropyl
BNF-referencedIsopropyl alcohol, also known as isopropanol or 2-propanol, is a colorless, flammable chemical compound with the molecular formula C3H8O. It is commonly used as a solvent, antiseptic, and disinfectant. Isopropyl alcohol has broad applications in medical, industrial, and household settings due to its effective antimicrobial properties and ability to dissolve a wide range of non-polar compounds.
Indications
- Antiseptic for skin disinfection
- Solvent in pharmaceutical formulations
- Cleaning agent in laboratories and healthcare settings
Dosage
Children: For pediatric use, consult specific guidelines in the BNF for Children, as dosing may vary based on age, weight, and clinical circumstances.
Adults: For skin antisepsis, apply isopropyl alcohol topically in a concentration of 70% to the affected area. Dosage may vary based on clinical indication and setting.
Mechanism of action
Isopropyl alcohol works primarily as an antiseptic by denaturing proteins and disrupting cell membranes of bacteria, viruses, and fungi, leading to cell lysis and death. Its efficacy is enhanced by the presence of water, which facilitates the penetration of the alcohol into microbial cells.
Pharmacodynamics
Isopropyl alcohol exhibits a rapid onset of action against a variety of pathogens, including gram-positive and gram-negative bacteria, fungi, and some viruses. Its antimicrobial activity is concentration-dependent, with higher concentrations generally providing a broader spectrum of activity. It is commonly used in concentrations ranging from 60% to 90%, with 70% being optimal for disinfection due to its ability to penetrate the cell wall effectively.
Pharmacokinetics
Isopropyl alcohol is readily absorbed through the skin and mucous membranes. After absorption, it is metabolized primarily in the liver to acetone, which is then further metabolized and excreted, mostly via urine. The elimination half-life of isopropyl alcohol varies but is typically around 2 to 3 hours. Its effects can be influenced by factors such as dosage, route of exposure, and individual metabolic differences.
Pregnancy
Isopropyl alcohol should be used with caution during pregnancy. It is a category C drug, indicating that risk cannot be ruled out.
Breast-feeding
Caution is advised when using isopropyl alcohol during breastfeeding, as it is not known if it is excreted in human milk.
Storage
Isopropyl alcohol should be stored at room temperature, away from heat and flame. Keep the container tightly closed and in a well-ventilated area.
Formulations
- Isopropyl alcohol 70% solution
- Isopropyl alcohol 99% solution
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Clinical monograph: opadry
Opadry is a film-coating system used in the pharmaceutical industry to coat tablets and granules. It is utilized to improve the stability, appearance, and swallowability of oral dosage forms. Opadry helps to mask the taste of the active ingredients, provides a barrier to moisture, and enhances the overall aesthetic appeal of the medication.
Indications
- Tablet coating
- Granule coating
- Improvement of drug stability
- Taste masking
- Aesthetic enhancement of pharmaceuticals
Dosage
Children: Dosage will depend on the specific formulation and active ingredients of the medication being coated. Refer to the specific product information for guidance.
Adults: Dosage will depend on the specific formulation and active ingredients of the medication being coated. Refer to the specific product information for guidance.
Mechanism of action
Opadry functions primarily as a coating polymer that adheres to the surface of tablets or granules, creating a protective layer. This layer can control the release of the active ingredient and protect it from environmental factors such as moisture and light. The specific composition of Opadry can vary, but it typically includes film-forming agents, plasticizers, and colorants that work together to achieve the desired coating characteristics.
Pharmacodynamics
The pharmacodynamics of Opadry is largely focused on its physical and chemical properties rather than specific biological interactions. The coating alters the dissolution characteristics of the drug, potentially leading to modified release profiles. This can enhance drug bioavailability or control the release rate of the active ingredient, thereby impacting the therapeutic effect.
Pharmacokinetics
As a coating agent, Opadry itself is not absorbed into the systemic circulation and does not have pharmacokinetic properties related to absorption, distribution, metabolism, or excretion of an active pharmaceutical ingredient. Its impact on pharmacokinetics is indirect, as it affects how the active drug is released and absorbed in the gastrointestinal tract.
Pregnancy
Opadry is a film-coating agent, and specific studies on its effects during pregnancy are not well-documented. Generally, it is advisable to use medications cautiously during pregnancy. Consult a healthcare provider for guidance.
Breast-feeding
Limited data are available regarding the safety of Opadry during breastfeeding. It is recommended to consult a healthcare provider before use.
Storage
Store in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children.
Formulations
- Opadry OY - a coating system for oral solid dosage forms
- Opadry II - a polymer-based coating system for tablet and capsule applications
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Clinical monograph: povidone
Povidone, also known as polyvinylpyrrolidone (PVP), is a synthetic polymer that is used as a water-soluble binder, stabilizer, and film-forming agent in various pharmaceutical formulations. It is recognized for its ability to enhance the solubility and bioavailability of drugs, making it valuable in both topical and oral therapies. Povidone has antiseptic properties and is commonly used in wound care, surgical scrubs, and as an excipient in medications.
Indications
- Topical antiseptic for skin disinfection
- Surgical scrubs and hand sanitizers
- Wound care management
- Pharmaceutical excipient in solid and liquid formulations
Dosage
Children: Refer to specific product guidelines for pediatric dosing recommendations, as doses can vary based on formulation and intended use.
Adults: Refer to specific product guidelines for dosing recommendations, as doses can vary based on the formulation and intended use.
Mechanism of action
Povidone acts by forming a complex with iodine when used as an antiseptic, which releases iodine slowly to exert its antimicrobial effect. The iodine disrupts microbial cell walls and interferes with protein synthesis, leading to cell death. Additionally, as a polymer, povidone can enhance drug solubility and stability by forming a hydrophilic matrix.
Pharmacodynamics
Povidone has a broad spectrum of antimicrobial activity against bacteria, viruses, and fungi. Its antiseptic properties are primarily due to the release of iodine, which is effective in reducing microbial load and preventing infection. The polymer's ability to bind to various substances allows it to be utilized in formulations that require improved stability and solubility.
Pharmacokinetics
Povidone is not absorbed systemically when applied topically, as it remains localized at the site of application. Its pharmacokinetics are largely dependent on the formulation and route of administration, with the polymer being metabolized by hydrolysis and excreted in urine as low-molecular-weight compounds. The release and activity of iodine are influenced by the concentration of povidone and the presence of organic matter.
Adverse effects
- Local irritation
- Allergic reactions
- Skin rashes
- Hypersensitivity reactions
Precautions
- Use with caution in patients with known allergies to iodine or povidone-iodine
- Avoid use in deep puncture wounds or serious burns
Pregnancy
Povidone is generally considered safe for use during pregnancy, but it is advisable to consult a healthcare professional before use.
Breast-feeding
Povidone is considered safe during breastfeeding, but it is recommended to consult a healthcare professional.
Storage
Store at room temperature, away from moisture and heat. Keep the container tightly closed.
Formulations
- Topical solution
- Ointment
- Surgical scrub
- Gauze impregnated with povidone-iodine
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: Alcohol
PubChem CID 702Molecular formula: C2H6O
Mechanism of action
Ethanol affects the brain’s neurons in several ways. It alters their membranes as well as their ion channels, enzymes, and receptors. Alcohol also binds directly to the receptors for acetylcholine, serotonin, GABA, and the NMDA receptors for glutamate. The sedative effects of ethanol are mediated through binding to GABA receptors and glycine receptors (alpha 1 and alpha 2 subunits). It also inhibits NMDA receptor functioning. In its role as an anti-infective, ethanol acts as an osmolyte or dehydrating agent that disrupts the osmotic balance across cell membranes. ... Ethanol is known to affect a large number of membrane proteins that participate in signaling pathways such as neurotransmitter receptors, enzymes, and ion channels, and there is extensive evidence that ethanol interacts with a variety of neurotransmitters. The major actions of ethanol involve enhancing the inhibitory effects of gamma-aminobutyric acid (GABA) at GABAa receptors and blockade of the N-methyl-D-aspartate (NMDA) subtype of glutamate, an excitatory amine acid (EAA) receptor. Animal studies indicate that the acute effects of ethanol result from competitive inhibition of glycine binding to NMDA receptor and disruption of glutamatergic neurotransmission by inhibiting the response of the NMDA receptor. Persistent glycine antagonism and attenuation of glutamatergic neurotransmission by chronic ethanol exposure results in tolerance to ethanol by enhancing EAA neurotransmission and NMDA receptor upregulation. The latter appears to involve selective increases in NMDA R2B subunit concentrations and other molecular changes in specific brain loci. The abrupt withdrawal of ethanol thus produces a hyperexcitable state that leads to the ethanol withdrawal syndrome and excitotoxic neuronal death. GABA-mediated inhibition, which normally acts to limit excitation, is eliminated during ethanol withdrawal syndrome and further intensifies this excitation. In addition, NMDA receptors function to inhibit the release of dopamine in the nucleus accumbens and mesolimbic structures, which modulate the reinforcing action of addictive xenobiotics such as ethanol. By inhibiting NMDA receptor activity, ethanol could increase dopamine release from the nucleus accumbens and ventral tegmental area and could thus create dependence. Chronic ethanol administration also results in tolerance, dependence, and an ethanol withdrawal syndrome, mediated, in part, by desensitization and or downregulation of GABAa receptors. The development of alcoholic ketoacidosis (AKA) requires that a combination of physical and physiologic events occur. The normal response to starvation and depletion of hepatic glycogen stores is for amino acids to be converted to pyruvate. Pyruvate can serve as a substrate for gluconeogenesis, be converted to acetyl-CoA, which can enter the Krebs cycle or can be utilized in various biosynthetic pathways (eg, fatty acid, ketone bodies, cholesterol, and acetylcholine) ... Ethanol metabolism generates NADH, resulting in an excess of reducing potential. This high redox state favors the conversion of pyruvate to lactate, diverting pyruvate from being a substrate for gluconeogenesis. To compensate for the lack of normal metabolic substrates, the body mobilizes fat from adipose tissue and increased fatty acid metabolism as an alternative source of energy. This response is mediated by a decrease in insulin and an increased secretion of glucagon, catecholamines, growth hormone, and cortisol. Fatty acid metabolism results in the formation of acetyl-CoA and it combines with the excess acetate that is generated from ethanol metabolism to form acetoacetate. Most of the acetoacetate is reduced to beta-hydroxybutyrate due to the excess reducing potential or high redox state of the cell. Volume depletion interferes with the renal elimination of acetoacetate and beta-hydroxybutyrate, and contributes to the acidosis. An elevated lactate concentration may result from shunting from pyruvate or
Pharmacodynamics
Alcohol produces injury to cells by dehydration and precipitation of the cytoplasm or protoplasm. This accounts for its bacteriocidal and antifungal action. When alcohol is injected in close proximity to nerve tissues, it produces neuritis and nerve degeneration (neurolysis). Ninety to 98% of ethanol that enters the body is completely oxidized. Ethanol is also used as a cosolvent to dissolve many insoluble drugs and to serve as a mild sedative in some medicinal formulations. Ethanol also binds to GABA, glycine, NMDA receptors and modulates their effects. Ethanol is also metabolised by the hepatic enzyme alcohol dehydrogenase.
Biological pathways
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
Molecular reference: Imatinib
PubChem CID 5291Molecular formula: C29H31N7O
Mechanism of action
Imatinib mesylate is a protein-tyrosine kinase inhibitor that inhibits the BCR-ABL tyrosine kinase, the constitutively active tyrosine kinase created by the Philadelphia chromosome abnormality in CML.Although the function of normal BCR is still unclear, ABL activation is overexpressed in various tumors and is heavily implicated in cancer cells growth and survival. Imatinib inhibits the BCR-ABL protein by binding to the ATP pocket in the active site, thus preventing downstream phosphorylation of target protein. Imatinib is also an inhibitor of the receptor tyrosine kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF), c-Kit, and inhibits PDGF- and SCF-mediated cellular events. In vitro, imatinib inhibits proliferation and induces apoptosis in GIST cells, which express an activating c-Kit mutation.
Pharmacodynamics
Imatinib is a 2-phenylaminopyrimidine derivative neoplastic agent that belongs to the class of tyrosine kinase inhibitors. Although imatinib inhibits a number of tyrosine kinases, it is quite selective toward the BCR-ABL fusion protein that is present in various cancers. BCR-ABL pathway controls many downstream pathways that are heavily implicated in neoplastic growth such as the Ras/MapK pathway (cellular proliferation), Src/Pax/Fak/Rac pathway (cellular motility), and PI/PI3K/AKT/BCL-2 pathway (apoptosis pathway). Therefore, the BCR-ABL pathway is an attractive target for cancer treatment. Although normal cells also depend on these pathways for growth, these cells tend to have redundant tyrosine kinases to continually function in spite of ABL inhibition from imatinib. Cancer cells, on the other hand, can have a dependence on BCR-ABL, thus more heavily impacted by imatinib.
Biological pathways
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
Molecular reference: isopropyl
PubChem CID 3776Molecular formula: C3H8O
Biological pathways
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.
- ARTEAR · Madawa Pharmaceuticals
- AVODINE MOUTHWASH AND GARGLE · Benmed Pharmaceuticals
- BETADINE ANTISEPTIC SOLUTION · Europa Healthcare
- BETADINE DRY POWDER SPRAY · Europa Healthcare
- BETADINE MOUTHWASH & GARGLE · Europa Healthcare
- BETADINE OINTMENT · Europa Healthcare
- BETASEP SOLUTION · Jamjoom Pharmaceuticals
- BLUPLEX INJECTION · Pharmax India
- DREZ OINTMENT (Each 10g/30g contains Iodinated Povidone/Metronidazole 10mg/30mg) · Stedman Pharmaceuticals
- DREZ POWDER · Stedman Pharmaceuticals
- DREZ TOPICAL SOLUTION · Stedman Pharmaceuticals
- DREZ TOPICAL SOLUTION · Stedman Pharmaceuticals