Iroflox Liquid Injection 50ml
ENROFLOXACININJECTION 10% W/V
What it does
Enrofloxacin is an antibiotic used to treat bacterial infections.
Commonly used for: bacterial infections, infections in pets (veterinary use)
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Source: Zambia Medicines Regulatory Authority · fetched 2026-03-12 00:02:19 · updated 2026-09-17 03:34:05
About this medicine
Enrofloxacin is an antibiotic used to treat bacterial infections.
What it treats
- bacterial infections
- infections in pets (veterinary use)
How it works
It works by stopping the growth of bacteria that cause infections.
Who it's for
This medication is mainly for animals, such as pets, suffering from bacterial infections.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: enrofloxacininjection
Enrofloxacin is a fluoroquinolone antibiotic that is primarily used in veterinary medicine. It is known for its broad-spectrum activity against both Gram-positive and Gram-negative bacteria, making it effective in treating various infections. Enrofloxacin is particularly noted for its use in small animals and livestock, where it can be administered via injection for rapid therapeutic effect.
Indications
- Bacterial infections
- Respiratory tract infections
- Urinary tract infections
- Skin infections
- Gastrointestinal infections
Dosage
Children: Refer to specific veterinary guidelines or the BNF for appropriate dosing information.
Adults: Refer to specific veterinary guidelines or the BNF for appropriate dosing information.
Mechanism of action
Enrofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, which are essential enzymes for bacterial DNA replication, transcription, and repair. By disrupting these processes, enrofloxacin prevents bacterial cell division and ultimately leads to cell death.
Pharmacodynamics
Enrofloxacin exhibits concentration-dependent bactericidal activity, meaning that its effectiveness increases with higher drug concentrations. It has a post-antibiotic effect, allowing for continued suppression of bacterial growth even after drug levels have fallen below the minimum inhibitory concentration (MIC). Its spectrum of activity includes a variety of pathogens, including Escherichia coli, Salmonella, and Staphylococcus species.
Pharmacokinetics
After administration, enrofloxacin is rapidly absorbed and reaches peak plasma concentrations within 1 to 2 hours. It has a bioavailability of approximately 80-100%. The drug is widely distributed in body tissues and fluids, including the lungs, kidneys, and liver. Enrofloxacin is metabolized primarily in the liver and is excreted through the kidneys and bile, with a half-life of about 5 to 7 hours in most species.
Contra-indications
- Hypersensitivity to enrofloxacin or other fluoroquinolones
- Tendon disorders related to fluoroquinolone treatment
- Severe renal impairment
Adverse effects
- Gastrointestinal disturbances (nausea, vomiting, diarrhea)
- Central nervous system effects (seizures, dizziness, headache)
- Tendon rupture or tendinopathy, especially in older patients
- Cartilage damage in growing animals (in veterinary use)
- Photosensitivity reactions
Interactions
- Antacids containing magnesium or aluminum may reduce absorption
- Nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of CNS stimulation
- Warfarin may have enhanced anticoagulant effect when used with enrofloxacin
Precautions
- Use with caution in patients with a history of seizures
- Monitor renal function during treatment
- Avoid use in young animals due to potential cartilage damage
- Consider alternative antibiotics in cases of severe infections
Pregnancy
Enrofloxacin is contraindicated during pregnancy due to potential harm to the fetus.
Breast-feeding
Use with caution in breastfeeding animals, as enrofloxacin can be excreted in milk.
Storage
Store at room temperature, away from light and moisture. Do not freeze.
Formulations
- Injectable solution for veterinary use
- Oral tablets for veterinary use
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.