KEPROMEC 10MG/ML INJECTION

Indications

• Onchocerciasis (river blindness)
• Lymphatic filariasis
• Strongyloidiasis
• Scabies
• Lice infestation
• Other parasitic infections

Dosage

Children: Refer to the BNF for Children for age-appropriate dosing recommendations.

Adults: Refer to appropriate prescribing guidelines for specific dosing regimens based on the condition being treated.

Mechanism of action

Kepromec works by binding to glutamate-gated chloride channels in the nerve and muscle cells of invertebrates. This action leads to an increase in the permeability of the cell membrane to chloride ions, resulting in hyperpolarization of the cells and subsequent paralysis or death of the parasite. Additionally, it may interact with other channels such as GABA-gated channels, further contributing to its antiparasitic effects.

Pharmacodynamics

The pharmacodynamic effects of kepromec include paralysis of parasites, leading to their eventual death. The drug exhibits a high degree of selectivity for invertebrate channels compared to mammalian channels, which underpins its safety profile in humans when used appropriately. The therapeutic window is generally favorable, allowing for effective treatment of parasitic infections while minimizing adverse effects.

Pharmacokinetics

Kepromec is well-absorbed following oral administration, with peak plasma concentrations occurring within 4 to 8 hours. It has a large volume of distribution, indicating extensive tissue binding. The drug is metabolized primarily in the liver, with a half-life ranging from 12 to 36 hours depending on the specific formulation and individual patient factors. Excretion occurs mainly through the feces, with minimal renal clearance.

Adverse effects

• Sedation
• Ataxia
• Hypotension
• Respiratory depression
• Extrapyramidal symptoms
• Anticholinergic effects

Interactions

• CNS depressants may enhance sedative effects
• Antihistamines may increase anticholinergic effects
• Use with caution in patients taking other medications that affect the central nervous system

Precautions

• Use with caution in patients with a history of seizures
• Monitor for signs of respiratory depression
• Caution in patients with cardiovascular disease

Pregnancy

Safety in pregnancy has not been established. Use only if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

It is not known whether this drug is excreted in human milk. Caution should be exercised when administering to nursing mothers.

Storage

Store in a cool, dry place, away from light. Keep out of reach of children.