KETESSE
DEXKETOPROFEN (AS TROMETAMOL SALT)
What it does
Dexketoprofen is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce inflammation.
Commonly used for: mild to moderate pain, muscle pain, joint pain, menstrual pain …
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 22:10:14 · updated 2026-05-08 07:59:53
Drug Interactions
14Pharmacodynamic Warnings
Dexketoprofen appears in TABLE 2: Drugs that cause nephrotoxicity
Dexketoprofen appears in TABLE 4: Drugs with antiplatelet effects
Dexketoprofen appears in TABLE 16: Drugs that increase serum potassium
Dexketoprofen appears in TABLE 18: Drugs that cause hyponatraemia
Severe (1)
Mifamurtide - decreases efficacy
NSAIDs(high-dose)arepredictedtodecreasetheefficacyof mifamurtide.Avoid.rTheoretical
Moderate (5)
Antiarrhythmics - increases exposure
NSAIDs (celecoxib) are predicted to increase the exposure to antiarrhythmics (flecainide, propafenone). Monitor and adjust dose.
Cladribine - increases exposure
NSAIDs(sulindac)mightincreasetheexposuretocladribine. Avoidoradjustdose.oTheoretical
Flecainide - increases exposure
NSAIDs (celecoxib) are predicted to increase the exposure to antiarrhythmics (flecainide, propafenone). Monitor and adjust dose.
Pemetrexed - increases exposure
NSAIDs are predicted to increase the exposure to pemetrexed. Use with caution or avoid. Also see TABLE 2 p. 1517
Propafenone - increases exposure
NSAIDs (celecoxib) are predicted to increase the exposure to antiarrhythmics (flecainide, propafenone). Monitor and adjust dose.
Unknown (8)
Alendronate - increases risk of gastrointestinal irritation
NSAIDs are predicted to increase the risk of gastrointestinal irritation when given with bisphosphonates (alendronate, ibandronate).
Bisphosphonates - increases risk of gastrointestinal irritation
NSAIDs are predicted to increase the risk of gastrointestinal irritation when given with bisphosphonates (alendronate, ibandronate).
Bisphosphonates - increases risk of renal impairment
NSAIDs are predicted to increase the risk of renal impairment when given with bisphosphonates (clodronate).
Clodronate - increases risk of renal impairment
NSAIDs are predicted to increase the risk of renal impairment when given with clodronate.
Deferasirox - increases risk of gastrointestinal bleeding
NSAIDs are predicted to increase the risk of gastrointestinal bleeding when given with deferasirox.
Deferiprone - increases exposure
NSAIDs(diclofenac)arepredictedtoincreasetheexposureto deferiprone.oTheoretical
Ibandronate - increases risk of gastrointestinal irritation
NSAIDs are predicted to increase the risk of gastrointestinal irritation when given with bisphosphonates (alendronate, ibandronate).
Ironchelators - increases risk of gastrointestinal bleeding
NSAIDs are predicted to increase the risk of gastrointestinal bleeding when given with iron chelators (deferasirox).
Data from BNF 85 (British National Formulary). This is not a substitute for professional medical advice. Matched via: class
About this medicine
Dexketoprofen is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce inflammation.
What it treats
- mild to moderate pain
- muscle pain
- joint pain
- menstrual pain
- post-operative pain
How it works
It works by blocking substances in the body that cause pain and inflammation.
Who it's for
It is suitable for adults who need relief from pain and inflammation.
Drug class
NSAIDs
Cautions
- • Avoid if taking drugs that can harm the kidneys.
- • Be cautious if using drugs that thin the blood.
- • Use with care if taking medications that can raise potassium levels.
- • Watch out if using drugs that can lower sodium levels in the body.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: Dexketoprofen
BNF-referencedDexketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, anti-inflammatory, and antipyretic properties. It is the S-enantiomer of ketoprofen and is primarily used for the relief of mild to moderate pain, including pain associated with musculoskeletal disorders, osteoarthritis, rheumatoid arthritis, and other inflammatory conditions.
Indications
- Pain and inflammation in musculoskeletal disorders
- Pain and inflammation in osteoarthritis
- Pain and inflammation in rheumatoid arthritis
- Pain relief in other mild to moderate pain conditions
Dosage
Children: Refer to BNF for Children for appropriate dosing information.
Adults: Adult: 12.5 mg every 4–6 hours, alternatively 25 mg every 8 hours; maximum 75 mg per day.
Mechanism of action
Dexketoprofen exerts its effects by reducing prostaglandin synthesis through the inhibition of the cyclooxygenase pathway, specifically targeting both COX-1 and COX-2 enzymes. This leads to decreased inflammation and pain signaling in the body.
Pharmacodynamics
As an isomer of ketoprofen, dexketoprofen is recognized for its analgesic and anti-inflammatory effects. It is classified as a propionic acid derivative, which means it shares similar properties with other drugs in this class, providing effective pain relief and reducing inflammation.
Pharmacokinetics
Dexketoprofen is rapidly absorbed after oral administration, with peak plasma concentrations typically occurring within 1-2 hours. It has a half-life of approximately 1-2 hours, allowing for relatively frequent dosing to maintain therapeutic effects. The drug is primarily metabolized in the liver and excreted via the kidneys, and dose adjustments may be necessary in patients with hepatic or renal impairment.
Contra-indications
- History of hypersensitivity to aspirin or any other NSAID
- Active gastrointestinal bleeding
- Active gastrointestinal ulceration
- Cerebrovascular disease
- Inflammatory bowel disease
- Ischaemic heart disease
- Mild to severe heart failure
- Peripheral arterial disease
Adverse effects
- Gastrointestinal discomfort
- Nausea
- Drowsiness
- Fluid retention
- Skin reactions
- Chest pain
- Myocardial infarction
- Depression
- Conjunctivitis
- Constipation
Interactions
- Concurrent use of fluconazole may require dose adjustment
- Risk of renal impairment with other NSAIDs or in patients with renal insufficiency
Precautions
- Use caution in patients with hepatic impairment
- Monitor blood pressure before and during treatment
- Long-term use may reduce female fertility, reversible on stopping treatment
Pregnancy
Avoid, as it is teratogenic in animal studies.
Breast-feeding
Avoid, as it is present in milk in animal studies.
Storage
Store at room temperature, away from moisture and heat.
Formulations
- 100 mg capsules
- 25 mg and 12.5 mg capsules
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: Dexketoprofen
PubChem CID 667550Molecular formula: C16H14O3
Mechanism of action
It is a non-steroidal anti-inflammatory drug (NSAID) that reduces prostaglandin synthesis via inhibition of cyclooxygenase pathway (both COX-1 and COX-2) activity.
Pharmacodynamics
This drug is an isomer of ketoprofen. Dexketoprofen a propionic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.
- KERAL 25 mg
- KERAL 25 mg GRANULES
- KERAL 50 mg/2 ml
- KETESSE 25 mg
- KETESSE 25 mg GRANULES
- KETESSE 50 mg/2 ml