LOPADINE EYE DROPS
OLOPATADINEHCL 1MG
What it does
Olopatadine is used to relieve allergy symptoms, such as itchy or watery eyes.
Commonly used for: allergic conjunctivitis, eye allergies
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 19:45:00 · updated 2026-08-03 02:54:02
About this medicine
Olopatadine is used to relieve allergy symptoms, such as itchy or watery eyes.
What it treats
- allergic conjunctivitis
- eye allergies
How it works
Olopatadine works by blocking the action of certain substances in the body that cause allergic symptoms.
Who it's for
It is suitable for adults and children who suffer from allergy-related eye problems.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: olopatadinehcl
Olopatadine hydrochloride is a selective antihistamine used primarily for the treatment of allergic conjunctivitis and allergic rhinitis. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Olopatadine is known for its dual action as both an antihistamine and a mast cell stabilizer, providing relief from ocular itching and inflammation associated with allergic reactions.
Indications
- Allergic conjunctivitis
- Allergic rhinitis
- Seasonal allergic rhinitis
Dosage
Children: Refer to the BNF for Children for specific dosing recommendations based on age and indication.
Adults: Refer to the BNF for specific dosing guidelines based on the formulation and indication.
Mechanism of action
Olopatadine acts as a selective antagonist of the H1 histamine receptor. By binding to these receptors, it inhibits the action of histamine, thereby reducing symptoms such as itching and redness in allergic reactions. Additionally, olopatadine stabilizes mast cells and prevents the release of histamine and other inflammatory mediators, contributing to its anti-inflammatory effects.
Pharmacodynamics
Olopatadine demonstrates a high affinity for H1 receptors, which leads to effective symptom relief in allergic conditions. Its mast cell stabilizing properties contribute to a decrease in the release of various inflammatory mediators, resulting in reduced ocular and nasal symptoms. The onset of action is typically rapid, with peak effects observed within hours after administration.
Pharmacokinetics
Olopatadine is well-absorbed after topical administration, with systemic absorption being minimal. It undergoes hepatic metabolism, primarily through glucuronidation, with renal excretion of metabolites. The elimination half-life allows for once or twice daily dosing, depending on the formulation used, either as an eye drop or nasal spray.
Adverse effects
- Headache
- Somnolence
- Dry mouth
- Nausea
- Fatigue
Precautions
- Use with caution in patients with severe renal impairment
- Not recommended in patients with hypersensitivity to olopatadine or any of the excipients
Pregnancy
Olopatadine should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Limited data is available on its safety during pregnancy.
Breast-feeding
Olopatadine is excreted in breast milk. Caution should be exercised when administering to nursing mothers.
Storage
Store at room temperature, away from light and moisture. Keep out of reach of children.
Formulations
- Ophthalmic solution (0.1% and 0.2%)
- Oral tablets (antihistamine formulations)
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.