Registered Malawi · PMRA

LULILEB 1%W/W CREAM

LULICONAZOLE

PMPB/PL253/110 CREAM dermatologicals INN generic

What it does

Luliconazole is a medication used to treat fungal skin infections.

Commonly used for: athlete's foot (tinea pedis), ringworm (tinea corporis), jock itch (tinea cruris)

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Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.

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Registration & product details

Registration no.
PMPB/PL253/110
Registration date
27/10/2021
Expiry date
31/03/2025
Status
Registered
Active ingredient
LULICONAZOLE
Dosage form
CREAM
Strength
-
Pack size
-
Therapeutic class
-
ATC class (WHO)
D01AC - Imidazole and triazole derivatives
Drug group
DERMATOLOGICALS
RxNorm RxCUI
1482680
Manufacturer / MAH
-
Applicant / LTR
-
Country of origin
-

Source: Pharmacy and Medicines Regulatory Authority · fetched 2026-04-21 17:37:39 · updated 2026-09-19 04:30:22

Disclaimer: This information is sourced from Pharmacy and Medicines Regulatory Authority (Malawi). Always consult a qualified healthcare professional before using any medication.

About this medicine

Luliconazole is a medication used to treat fungal skin infections.

What it treats

  • athlete's foot (tinea pedis)
  • ringworm (tinea corporis)
  • jock itch (tinea cruris)

How it works

It works by stopping the growth of the fungus that causes the infection.

Who it's for

It is for adults and children over the age of 12 who have a fungal skin infection.

AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.

Clinical monograph: luliconazole

BNF-referenced

Luliconazole is an antifungal agent primarily used for the treatment of dermatophyte infections. It is effective against various fungal pathogens, particularly those affecting the skin. Luliconazole is formulated as a topical solution and is known for its relatively low side effect profile and ease of application. Its use has been increasingly recognized in the management of superficial fungal infections.

Indications

  • Tinea corporis
  • Tinea cruris
  • Tinea pedis
  • Dermatophyte infections

Dosage

Children: Refer to the BNF for Children for specific dosing recommendations for pediatric patients.

Adults: Apply a thin layer of luliconazole to the affected area once daily for a duration of 1 to 2 weeks, depending on the specific infection being treated.

Mechanism of action

The exact mechanism of action for luliconazole's antifungal activity is not fully understood, but it is believed to inhibit the enzyme lanosterol demethylase. This enzyme is essential for the synthesis of ergosterol, which is a critical component of fungal cell membranes. By inhibiting this enzyme, luliconazole disrupts the integrity of the fungal cell membrane, leading to cell death.

Pharmacodynamics

Luliconazole demonstrates fungicidal activity against organisms like Trichophyton rubrum and Epidermophyton floccosum. Its action is thought to be primarily through the alteration of fungal cell membranes, which compromises the structure and function of the fungi, ultimately leading to their death.

Pharmacokinetics

Luliconazole is administered topically, which limits its systemic absorption. The pharmacokinetics of luliconazole involve localized action at the site of application, minimizing the risk of systemic side effects. Due to its topical formulation, specific pharmacokinetic parameters such as absorption, distribution, metabolism, and excretion in humans are not extensively detailed in the literature.

Adverse effects

  • Application site reactions
  • Burning sensation
  • Itching
  • Erythema

Precautions

  • Avoid contact with eyes
  • Do not apply to broken skin

Pregnancy

Luliconazole should only be used in pregnancy if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

Caution should be exercised when luliconazole is administered to nursing mothers.

Storage

Store at room temperature, away from moisture and heat.

Formulations

  • Topical cream
PubChem / pathway

AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.

Molecular reference: luliconazole

PubChem CID 3003141

Molecular formula: C14H9Cl2N3S2

Mechanism of action

The exact mechanism of action for luliconazole's anti-fungal activity is still not known, but luliconazole is thought to inhibit the enzyme lanosterol demethylase. Lanosterol demethylase is needed for the synthesis of ergosterol, which is a major component of the fungus cell membranes.

Pharmacodynamics

Luliconazole kills the organisms Trichophyton rubrum and Epidermophyton floccosum, most likely by altering their fungal cell membranes.

Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.

This drug in other countries

The same active ingredient registered across other registries we cover - including different brands.

Kenya 10 products
View all 10 in Kenya →
Tanzania 6 products
Zambia 2 products
Zimbabwe 1 product