LYMECYCLINE ACTIVO

Indications

• Bacterial infections
• Acne vulgaris (adjunct to topical treatment)
• Chlamydia infections
• Rickettsial infections
• Mycoplasma infections

Dosage

Children: For children aged 12–17 years, the recommended dosage is 408 mg once daily. For specific pediatric dosing, refer to the BNF for Children.

Adults: For adults, the typical dosage of Lymecycline is 408 mg once daily, which can be increased to 1.224–1.632 g daily in severe infections.

Mechanism of action

Lymecycline exerts its antibacterial effect by binding to the 30S ribosomal subunit of bacteria, inhibiting the attachment of aminoacyl-tRNA to the mRNA-ribosome complex. This action prevents protein synthesis, which is essential for bacterial growth and reproduction.

Pharmacodynamics

Lymecycline has a broad spectrum of activity against gram-positive and gram-negative bacteria. It is particularly effective against susceptible strains of bacteria responsible for respiratory tract infections, urinary tract infections, and certain sexually transmitted infections. Its efficacy is partly due to its ability to penetrate bacterial cells and accumulate at the site of action.

Pharmacokinetics

Lymecycline is absorbed well from the gastrointestinal tract, with peak plasma concentrations typically occurring 1-2 hours after oral administration. It has a bioavailability of approximately 60-70%. The drug is primarily excreted in the urine, both as unchanged drug and metabolites, with a half-life of about 8-12 hours. Adjustments may be necessary in cases of renal impairment.

Contra-indications

• Hypersensitivity to lymecycline or other tetracyclines
• Severe renal impairment
• Pregnancy (especially during the first trimester)

Adverse effects

• Gastrointestinal discomfort
• Photosensitivity
• Visual impairment
• Skin hyperpigmentation (with long-term use)
• Severe cutaneous adverse reactions (SCARs)
• Tinnitus

Interactions

• Antacids containing aluminum, calcium, or magnesium may reduce absorption
• Iron supplements may also decrease the absorption of lymecycline
• Concurrent use with other nephrotoxic drugs should be approached with caution

Precautions

• Caution in patients with renal impairment
• Monitor for signs of fungal infections, particularly in those predisposed to oral candidiasis
• Avoid excessive sun exposure due to risk of photosensitivity

Pregnancy

Lymecycline is contraindicated during pregnancy, particularly in the first trimester; however, it may be considered if the entire treatment course can be completed before 15 weeks' gestation in unavoidable malaria prophylaxis.

Breast-feeding

Lymecycline should be used with caution during breastfeeding as it may be excreted in breast milk.

Storage

Store in a refrigerator (2–8°C) and protect from light.

Formulations

• Lymecycline 408 mg capsules