MASTIWOK
CEFOPERAZONE
What it does
Cefoperazone is an antibiotic used to treat various infections caused by bacteria.
Commonly used for: infections of the lungs (pneumonia), infections of the urinary tract, infections of the skin, bacterial infections in the bloodstream
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 21:23:58 · updated 2026-07-20 10:58:00
About this medicine
Cefoperazone is an antibiotic used to treat various infections caused by bacteria.
What it treats
- infections of the lungs (pneumonia)
- infections of the urinary tract
- infections of the skin
- bacterial infections in the bloodstream
How it works
It works by stopping the growth of bacteria, helping the body to fight off the infection.
Who it's for
Cefoperazone is for individuals with bacterial infections who need antibiotic treatment.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: cefoperazone
BNF-referencedCefoperazone is a third generation cephalosporin antibiotic that is effective against a variety of Gram-negative and some Gram-positive bacteria. It is primarily used in the treatment of serious infections due to its broad-spectrum activity and resistance to certain beta-lactamases. It is often utilized in hospital settings for infections such as pneumonia, sepsis, and infections caused by resistant organisms.
Indications
- Bacterial infections
- Pneumonia
- Sepsis
- Intra-abdominal infections
- Skin and soft tissue infections
- Urinary tract infections
Dosage
Children: Refer to the BNF for Children for specific dosage information.
Adults: Refer to the BNF for specific dosage information.
Mechanism of action
Cefoperazone binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall. This binding inhibits the third and final stage of bacterial cell wall synthesis. The result is cell lysis, which is facilitated by bacterial cell wall autolytic enzymes such as autolysins.
Pharmacodynamics
As a third generation cephalosporin, cefoperazone exerts a bactericidal effect by inhibiting bacterial cell wall synthesis. This mechanism is critical for its effectiveness against a range of pathogens, particularly those that are resistant to other antibiotics.
Pharmacokinetics
Cefoperazone is administered parenterally and has a half-life that allows for once or twice daily dosing. It is widely distributed in body tissues and fluids, including the central nervous system. Cefoperazone is primarily eliminated by the kidneys, with a portion also excreted in bile, making it suitable for treating infections in patients with renal impairment, although dosage adjustments may be necessary.
Contra-indications
- Hypersensitivity to cefoperazone or other beta-lactam antibiotics
- History of severe allergic reactions to any cephalosporin
Adverse effects
- Diarrhea
- Nausea
- Vomiting
- Rash
- Elevated liver enzymes
- Thrombocytopenia
- Neutropenia
Interactions
- Probenecid may increase cefoperazone levels by reducing renal excretion
- Concurrent use with aminoglycosides may enhance nephrotoxicity
- Potential interaction with anticoagulants leading to increased bleeding risk
Precautions
- Use with caution in patients with renal impairment
- Monitor liver function tests during therapy
- May cause false-positive results for urine glucose tests
Pregnancy
Cefoperazone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
Cefoperazone is excreted in breast milk; caution should be exercised when administered to nursing mothers.
Storage
Store at room temperature, away from light and moisture. Reconstituted solutions should be stored in the refrigerator and used within a specified time frame as per manufacturer guidelines.
Formulations
- Cefoperazone sodium for injection
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: cefoperazone
PubChem CID 44187Molecular formula: C25H27N9O8S2
Mechanism of action
Like all beta-lactam antibiotics, cefoperazone binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.
Pharmacodynamics
Cefoperazone is a third generation cephalosporin antibiotic. Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.