MEBO OINTMENT

Indications

• Hyperlipidemia
• Cardiovascular disease prevention
• Benign prostatic hyperplasia

Dosage

Children: Refer to BNF for Children for specific dosing recommendations as there is no standard paediatric dosage provided.

Adults: Refer to BNF for specific dosing recommendations as there is no standard adult dosage provided.

Mechanism of action

Bsitosterol primarily functions by inhibiting the absorption of cholesterol in the intestines. It competes with cholesterol for incorporation into micelles, which are necessary for efficient absorption. This mechanism results in decreased serum cholesterol levels and may contribute to improved cardiovascular health. Additionally, it may influence steroid biosynthesis pathways and plant sterol biosynthesis.

Pharmacodynamics

Bsitosterol exerts its effects by modulating lipid metabolism, particularly by lowering low-density lipoprotein (LDL) cholesterol levels without significantly affecting high-density lipoprotein (HDL) cholesterol. Its actions may help in reducing the risk of atherosclerosis and other cardiovascular diseases. The pharmacodynamic profile includes anti-inflammatory properties and potential benefits in benign prostatic hyperplasia (BPH).

Pharmacokinetics

The absorption of bsitosterol occurs in the gastrointestinal tract, where it competes with dietary cholesterol. It is absorbed in small amounts, and its bioavailability is relatively low. Bsitosterol is metabolized primarily in the liver, with some conversion to more active metabolites involved in steroid biosynthesis pathways. The elimination half-life and specific excretion pathways are not well-defined, but it is thought to be excreted via the biliary route.

Pregnancy

Bsitosterol is classified as a category C drug. There are no adequate and well-controlled studies in pregnant women. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

It is unknown whether bsitosterol is excreted in human milk. Caution should be exercised when administering to breastfeeding women.

Storage

Store at room temperature, away from moisture and heat. Keep the container tightly closed.

Formulations

• Capsules
• Tablets
• Powder