International reference: 3 US FDA recalls for this ingredient
Failed Dissolution Specifications: An out-of-specification (OOS) result was observed during the 9th month of dissolution test analysis (minocycline)
Labeling: Label Mixup: MINOCYCLINE HCL, Capsule, 100 mg may have potentially been mislabeled as the following drug: PROGESTERONE, Capsule, 100 mg, NDC 00591396401, Pedigree: AD73611_4, EXP: 5/30/2014. (minocycline)
Lack of Processing Controls (minocycline)
US-market enforcement records (OpenFDA), shown for reference - not specific to this product in Malawi.
MINOCYCLINE 100MG CAPSULE
MINOCYCLINE HYDROCHLORIDE
What it does
Minocycline is an antibiotic used to treat various infections.
Commonly used for: acne, skin infections, respiratory tract infections, chlamydia (a type of sexually transmitted infection)
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Sourcing - Kenya onlyRegistration & product details
Source: Pharmacy and Medicines Regulatory Authority · fetched 2026-04-21 17:37:38 · updated 2026-09-19 04:30:21
Drug Interactions
8Pharmacodynamic Warnings
Minocycline appears in TABLE 1: Drugs that cause hepatotoxicity
Severe (1)
Tetracyclines - decreases absorption
Strontium is predicted to decrease the absorption of tetracyclines. Avoid. Theoretical Sucralfate
Moderate (3)
Lithium - increases risk of lithium toxicity
Tetracyclines are predicted to increase the risk of lithium toxicity when given with lithium. Avoid or adjust dose.
Tetracyclines - decreases concentration
Fosphenytoin is predicted to decrease the concentration of tetracyclines (doxycycline). Adjust dose.
Tetracyclines - decreases exposure
Rifampicin modestly decreases the exposure to tetracyclines (doxycycline). Adjust dose.
Unknown (4)
Tetracyclines - decreases exposure
Mitotane is predicted to decrease the exposure to tetracyclines (eravacycline). Adjust eravacycline dose, p. 625.
Tetracyclines - decreases exposure
Rifampicin is predicted to decrease the exposure to tetracyclines (eravacycline). Adjust eravacycline dose, p. 625.
Tetracyclines - decreases exposure
St John's wort is predicted to decrease the exposure to tetracyclines (eravacycline). Adjust eravacycline dose, p. 625.
Tetracyclines - decreases absorption
Oralzincispredictedtodecreasetheabsorptionof tetracyclines.Separateadministrationby2to3hours. oTheoretical https://www.facebook.c (Books-Courses-Medic
Data from BNF 85 (British National Formulary). This is not a substitute for professional medical advice. Matched via: class
About this medicine
Minocycline is an antibiotic used to treat various infections.
What it treats
- acne
- skin infections
- respiratory tract infections
- chlamydia (a type of sexually transmitted infection)
How it works
It works by stopping the growth of bacteria that cause infections.
Who it's for
Minocycline is for adults and children over 8 years old who need treatment for bacterial infections.
Drug class
Tetracyclines
Cautions
- • Avoid using with other medications that can harm the liver.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: Minocycline
BNF-referencedMinocycline is a broad-spectrum antibiotic belonging to the tetracycline class. It is effective against a variety of gram-positive and gram-negative bacteria, as well as certain protozoa. It is commonly used to treat various bacterial infections, including acne vulgaris, respiratory tract infections, and certain sexually transmitted infections. Minocycline has the ability to penetrate tissues and achieve therapeutic concentrations in various body compartments, making it suitable for treating infections in areas like the skin and lungs.
Indications
- Bacterial infections
- Acne vulgaris (adjunct to topical treatment)
- Chlamydia infections
- Rickettsial infections
- Mycoplasma infections
- Respiratory tract infections
Dosage
Children: For children aged 12-17 years, the recommended dosage is 408 mg once daily. Consultation with the BNF for Children is advised for precise dosing guidelines and adjustments based on clinical conditions.
Adults: For adults, the typical dosage is 408 mg once daily, which may be increased to 1.224–1.632 g daily in severe infections. It is important to refer to the BNF for specific indications and detailed dosing recommendations.
Mechanism of action
Minocycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thus preventing the incorporation of amino acids into peptides. This action effectively stops bacterial growth and replication. The drug is also thought to possess anti-inflammatory properties, which can be beneficial in treating conditions like acne.
Pharmacodynamics
Minocycline displays time-dependent bactericidal activity against susceptible bacteria. Its pharmacodynamic profile indicates a prolonged post-antibiotic effect, which means that the antibacterial effect persists even after the drug concentration falls below the minimum inhibitory concentration (MIC). This property can enhance its effectiveness against certain pathogens.
Pharmacokinetics
Minocycline is well-absorbed from the gastrointestinal tract, with an oral bioavailability of approximately 90%. It is widely distributed throughout the body, including the central nervous system, and has a half-life of about 11 to 22 hours. The drug is metabolized in the liver and excreted primarily in urine and feces. Adjustments may be necessary in cases of renal impairment.
Contra-indications
- Known hypersensitivity to minocycline or other tetracyclines
- Pregnancy (particularly during the first trimester due to risk of fetal harm)
- Severe hepatic impairment
- Severe renal impairment
Adverse effects
- Gastrointestinal discomfort
- Photosensitivity
- Skin hyperpigmentation with long-term use
- Visual impairment
- Severe cutaneous adverse reactions (e.g. SCARs)
- Dental staining and hypoplasia in children
Interactions
- Antacids containing aluminum, calcium, or magnesium can reduce absorption
- Iron supplements may reduce efficacy
- Other tetracyclines may have additive effects
- Isotretinoin may increase risk of intracranial hypertension
Precautions
- Use with caution in patients with renal impairment
- Monitor for signs of fungal infections, particularly in patients with a predisposition
- Advise patients to avoid excessive sun exposure
- Monitor for visual disturbances during treatment
Pregnancy
Minocycline should not be used during pregnancy, especially in the first trimester, due to potential risks to the fetus including bone and teeth development issues.
Breast-feeding
Minocycline is excreted in breast milk; caution is advised if used while breastfeeding.
Storage
Store in a refrigerator (2–8°C) and protect from light. Consult product literature for storage after dilution.
Formulations
- Capsules
- Tablets
- Oral suspension
- Powder for reconstitution
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: Minocycline
PubChem CID 54675783Molecular formula: C23H27N3O7
Biological pathways
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.