MOISOL
HYDROXYPROYLMETHYLCELLULOSE
What it does
Hydroxypropylmethylcellulose is a substance used to help lubricate and protect areas of the body, such as the eyes.
Commonly used for: dry eyes, ocular dryness
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
Ask about this medicine
Answers come only from this medicine's registration record, BNF monograph and interaction data - not medical advice.
Medicine sourcing is available in Kenya only. We don't sell or dispense medicines - licensed pharmacies do.
Sourcing - Kenya onlyRegistration & product details
Source: Medicines Control Authority of Zimbabwe · fetched 2026-04-18 08:22:09 · updated 2026-10-21 04:30:07
About this medicine
Hydroxypropylmethylcellulose is a substance used to help lubricate and protect areas of the body, such as the eyes.
What it treats
- dry eyes
- ocular dryness
How it works
It forms a protective layer on the surface of the eyes, helping to keep them moist and comfortable.
Who it's for
People experiencing dryness or irritation in their eyes.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: hydroxyproylmethylcellulose
Hydroxypropylmethylcellulose (HPMC) is a semi-synthetic polymer derived from cellulose. It is commonly used as a thickening agent, emulsifier, and film-forming agent in various pharmaceutical and cosmetic formulations. HPMC is particularly noted for its use in ophthalmic preparations, where it serves as a lubricant to alleviate dry eye symptoms and enhance the comfort of contact lenses.
Indications
- Dry eye syndrome
- Ocular surface lubrication
- Contact lens comfort
Dosage
Children: Refer to specific product guidelines for administration instructions, as pediatric dosing may vary based on formulation and indication.
Adults: Refer to specific product guidelines for administration instructions, typically involving one to two drops in the affected eye(s) as needed.
Mechanism of action
Hydroxypropylmethylcellulose acts as a viscoelastic agent by forming a gel-like consistency upon hydration. This property allows it to retain moisture and provide lubrication to the ocular surface, reducing friction during blinking and providing relief from dryness. It can also stabilize the tear film and prolong the retention time of the drug in the eye.
Pharmacodynamics
HPMC does not have systemic pharmacodynamic effects as it primarily acts locally. Its lubricating properties improve ocular surface moisture, enhance comfort, and facilitate the healing of minor ocular surface injuries. The viscosity and bioadhesive nature of HPMC contribute to its effectiveness in maintaining tear film stability.
Pharmacokinetics
Due to its large molecular weight and structure, hydroxypropylmethylcellulose is not readily absorbed through biological membranes. Its effects are primarily local, with minimal systemic absorption. The elimination of HPMC from the ocular surface occurs through natural tear turnover and drainage.
Adverse effects
- Allergic reactions
- Eye irritation
- Dry eyes
- Vision disturbances
Precautions
- Use caution in patients with a history of hypersensitivity to cellulose derivatives
- Consult a healthcare provider before use in patients with pre-existing eye conditions
Pregnancy
Hydroxypropylmethylcellulose is generally considered safe for use during pregnancy, but it is advisable to consult a healthcare provider.
Breast-feeding
Hydroxypropylmethylcellulose is not known to be excreted in human milk. It is considered safe for use while breastfeeding, but consultation with a healthcare provider is recommended.
Storage
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
Formulations
- Ophthalmic solution
- Ophthalmic gel
- Oral capsule
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.