Registered Kenya · PPB

MOSID-MT 5

MOSAPRIDE CITRATE DIHYDRATE

14752 5 MG alimentary tract and metabolism INN generic

What it does

Mosapride is a medication that helps with digestive issues by improving gut movement.

Commonly used for: stomach discomfort, gastroesophageal reflux disease (GERD), functional dyspepsia

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Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.

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Registration & product details

Registration no.
14752
Registration date
-
Expiry date
-
Status
Registered
Active ingredient
MOSAPRIDE CITRATE DIHYDRATE
Dosage form
5 MG
Strength
-
Pack size
-
Therapeutic class
-
ATC class (WHO)
A03FA - Propulsives
Drug group
ALIMENTARY TRACT AND METABOLISM
RxNorm RxCUI
135091
Manufacturer / MAH
Medox Pharmaceuticals
Applicant / LTR
-
Country of origin
FOREIGN
Manufacturer location
P.NO.28, BLOCK J OFF SETH BENJAMIN STREET,, Arusha 16227, Tanzania

Source: Pharmacy and Poisons Board · fetched 2026-01-28 21:31:15 · updated 2026-07-20 11:05:24

Disclaimer: This information is sourced from Pharmacy and Poisons Board (Kenya). Always consult a qualified healthcare professional before using any medication.

About this medicine

Mosapride is a medication that helps with digestive issues by improving gut movement.

What it treats

  • stomach discomfort
  • gastroesophageal reflux disease (GERD)
  • functional dyspepsia

How it works

It works by enhancing the motility of the gastrointestinal tract, helping food move more easily through the stomach and intestines.

Who it's for

This medication is for adults experiencing digestive problems like bloating, heartburn, or nausea.

AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.

Clinical monograph: mosapride

BNF-referenced

Mosapride is a gastroprokinetic agent primarily used in the treatment of gastrointestinal disorders such as functional dyspepsia and gastroesophageal reflux disease (GERD). It enhances gastrointestinal motility by acting on serotonin receptors and is effective in improving symptoms associated with dyspepsia, including abdominal pain, bloating, and early satiety.

Indications

  • Functional dyspepsia
  • Gastroesophageal reflux disease (GERD)
  • Gastric motility disorders

Dosage

Children: For children, dosage must be determined based on clinical guidelines; refer to the BNF for Children for specific dosing recommendations.

Adults: The usual adult dosage of mosapride is 5 mg taken three times daily before meals.

Mechanism of action

Mosapride acts as a selective 5-HT4 receptor agonist, which stimulates the release of acetylcholine in the gastrointestinal tract, enhancing peristalsis and accelerating gastric emptying. This mechanism contributes to its efficacy in alleviating symptoms of gastrointestinal motility disorders.

Pharmacodynamics

The pharmacodynamics of mosapride involve its action on the central and peripheral nervous systems through serotonin receptor modulation. It primarily enhances gastrointestinal motility by increasing the rate of gastric emptying and improving esophageal motility. In addition to its prokinetic effects, mosapride has been noted to have an influence on visceral sensitivity, which may help in reducing discomfort associated with functional gastrointestinal disorders.

Pharmacokinetics

Mosapride is well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring approximately 1-2 hours after oral administration. It has a half-life of around 10 hours, allowing for once or twice daily dosing. The drug is extensively metabolized in the liver, primarily via cytochrome P450 enzymes, and is excreted mainly in the urine as metabolites. The pharmacokinetics may be influenced by factors such as liver function and age.

Adverse effects

  • Diarrhoea
  • Constipation
  • Nausea
  • Vomiting
  • Abdominal pain
  • Headache
  • Dizziness
  • Fatigue

Precautions

  • Use with caution in patients with renal impairment
  • Monitor for gastrointestinal symptoms
  • Consider potential interactions with other medications

Pregnancy

Mosapride should only be used during pregnancy if the benefits outweigh the risks, as there is limited data on its safety in pregnant women.

Breast-feeding

Mosapride is excreted in breast milk; caution is advised when administering to breastfeeding mothers.

Storage

Store at room temperature, away from moisture and direct sunlight.

Formulations

  • Tablets
  • Oral suspension
PubChem / pathway

AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.

Molecular reference: mosapride

PubChem CID 119584

Molecular formula: C21H25ClFN3O3

Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.