MUCOPAIN
BENZOCAINE USP
What it does
Benzocaine is a local anesthetic that numbs the skin or mucous membranes to relieve pain or discomfort.
Commonly used for: sore throat, mouth ulcers, toothache, minor burns …
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 22:11:59 · updated 2026-03-23 04:57:10
About this medicine
Benzocaine is a local anesthetic that numbs the skin or mucous membranes to relieve pain or discomfort.
What it treats
- sore throat
- mouth ulcers
- toothache
- minor burns
- insect bites
How it works
Benzocaine works by blocking the nerve signals in the area where it is applied, reducing pain and discomfort.
Who it's for
Benzocaine is suitable for adults and children who need relief from localized pain.
Cautions
- • Do not use if you are allergic to benzocaine or similar products.
- • Avoid use on large areas of skin or on deep wounds.
- • Consult a doctor if symptoms persist or worsen.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: benzocaine
BNF-referencedBenzocaine is a local anesthetic commonly used for its analgesic properties. It is primarily applied topically to relieve pain and discomfort associated with minor skin irritations, sore throat, and dental procedures. Its quick onset and short duration of action make it suitable for various temporary applications.
Indications
- Topical anesthesia for minor skin irritations
- Sore throat relief
- Dental procedures
Dosage
Children: Refer to the BNF for Children for specific dosing recommendations.
Adults: Apply a thin layer to the affected area as needed, not exceeding the recommended frequency in product guidelines.
Mechanism of action
Benzocaine diffuses into nerve cells where it binds to sodium channels, preventing the channels from opening, and blocking the influx of sodium ions. Nerve cells unable to allow sodium into cells cannot depolarize and conduct nerve impulses. Benzocaine reversibly stabilizes the neuronal membrane, decreasing its permeability to sodium ions, thereby inhibiting depolarization of the neuronal membrane and blocking the initiation and conduction of nerve impulses.
Pharmacodynamics
Benzocaine is indicated for use as a topical anesthetic. It has a duration of action of approximately 10 minutes and a wide therapeutic window. Patients should be counselled regarding the risks of methemoglobinemia, a rare but serious condition that can occur with excessive use.
Pharmacokinetics
Benzocaine is poorly soluble in water, which limits its systemic absorption when applied topically. It is rapidly absorbed through the skin, and its effects are localized. The half-life and metabolism details are not extensively documented, but the drug is primarily metabolized in the liver. Clearance from the system generally occurs within a short time frame, correlating with its brief duration of action.
Adverse effects
- Methemoglobinemia
- Allergic reactions
- Local irritation
- Skin rash
Precautions
- Use with caution in patients with a history of methemoglobinemia
- Not for use on large areas of damaged skin or mucous membranes
- Avoid contact with eyes
Pregnancy
Benzocaine should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult a healthcare professional.
Breast-feeding
Benzocaine is generally considered safe for use during breastfeeding, but caution is advised. Consult a healthcare professional for specific recommendations.
Storage
Store in a cool, dry place, away from direct sunlight. Keep out of reach of children.
Formulations
- Topical cream
- Topical gel
- Topical ointment
- Lozenges
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: benzocaine
PubChem CID 2337Molecular formula: C9H11NO2
Mechanism of action
Benzocaine diffuses into nerve cells where it binds to sodium channels, preventing the channels from opening, and blocking the influx of sodium ions. Nerve cells unable to allow sodium into cells cannot depolarize and conduct nerve impulses. Benzocaine reversibly stabilizes the neuronal membrane with decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.
Pharmacodynamics
Benzocaine is indicated for use as a topical anesthetic. It has a duration of action of approximately 10 minutes and a wide therapeutic window. Patients should be counselled regarding the risks of methemoglobinemia.
Biological pathways
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.