MYLOVASC 5 TABLETS
S-Amlodipine besilate 5mg
What it does
S-amlodipine is a medication used to help lower blood pressure and improve blood flow.
Commonly used for: high blood pressure (hypertension), chest pain (angina)
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Rwanda Food and Drugs Authority · fetched 2026-03-11 22:07:19 · updated 2026-09-17 02:30:43
About this medicine
S-amlodipine is a medication used to help lower blood pressure and improve blood flow.
What it treats
- high blood pressure (hypertension)
- chest pain (angina)
How it works
It relaxes and widens blood vessels, making it easier for the heart to pump blood.
Who it's for
It is for adults who need help managing their blood pressure or reducing chest pain.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: samlodipine
BNF-referencedSamlodipine is a calcium channel blocker primarily used in the management of hypertension and angina pectoris. It functions by relaxing vascular smooth muscle and promoting vasodilation, thereby reducing blood pressure and improving blood flow to the heart. This drug is particularly effective in reducing peripheral vascular resistance, making it beneficial for patients with elevated blood pressure.
Indications
- Hypertension
- Angina pectoris
Dosage
Children: 1.25-2.5 mg once daily.
Adults: 2.5-5 mg once daily.
Mechanism of action
Levamlodipine blocks the transmembrane influx of calcium through L-type calcium channels into the vascular and cardiac smooth muscles. This results in vasodilation and a decrease in blood pressure. It inhibits calcium influx in vascular smooth muscle more significantly than in cardiac muscle, leading to decreased peripheral vascular resistance and lower blood pressure. Although in vitro studies have shown a negative inotropic effect, this is unlikely to be clinically relevant.
Pharmacodynamics
Levamlodipine inhibits L-type calcium channels in vascular smooth muscle, leading to reduced peripheral vascular resistance and blood pressure. It is administered once daily, and patients should be informed about potential side effects, including symptomatic hypotension, worsening angina, and myocardial infarction.
Pharmacokinetics
The pharmacokinetics of samlodipine include its absorption, distribution, metabolism, and excretion. It is generally well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring several hours after oral administration. The drug has a long elimination half-life, allowing for once-daily dosing. It is metabolized in the liver and excreted primarily through the kidneys.
Adverse effects
- symptomatic hypotension
- worsening angina
- myocardial infarction
Pregnancy
Caution is advised, as safety during pregnancy has not been established.
Breast-feeding
Caution is advised, as it is not known if samlodipine is excreted in human milk.
Storage
Store at room temperature, away from direct sunlight and moisture.
Formulations
- tablets
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: s-amlodipine
PubChem CID 9822750Molecular formula: C20H25ClN2O5
Mechanism of action
Levamlodipine blocks the transmembrane influx of calcium through L-type calcium channels into the vascular and cardiac smooth muscles resulting in vasodilation and a subsequent decrease in blood pressure. Levamlodipine inhibits calcium influx in vascular smooth muscle to a greater degree than in cardiac muscle, leading to decreased peripheral vascular resistance and lowered blood pressure. In vitro studies have shown a negative inotropic effect but this is unlikely to be clinically relevant.
Pharmacodynamics
Levamlodipine inhibits L-type calcium channels in vascular smooth muscle, reducing peripheral vascular resistance and blood pressure. It is given once daily in doses of 1.25-2.5mg in children and 2.5-5mg in adults. Patients should be counselled regarding the risk of symptomatic hypotension, worsening angina, and myocardial infarction.
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.