NADIMIX CREAM
NADIFLOXACIN, MICONAZOLE NITRATE, MOMETASONE FUROATE
What it does
Miconazole is an antifungal medication used to treat fungal infections on the skin and in the mouth.
Commonly used for: fungal infections of the skin, oral thrush (fungal infection in the mouth)
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 19:51:03 · updated 2026-08-03 03:11:30
Drug Interactions
83Severe (6)
Antihistamines,non-Sedating - increases exposure
Miconazole is predicted to increase the exposure to antihistamines, non-sedating (mizolastine). Avoid.
Ergometrine - increases exposure
Miconazoleispredictedtoincreasetheexposureto ergometrine.Avoid.oTheoretical
Ergotamine - increases exposure
Miconazoleispredictedtoincreasetheexposureto ergotamine.Avoid.oTheoretical
Mifamurtide - decreases efficacy
Corticosteroidsarepredictedtodecreasetheefficacyof mifamurtide.Avoid.rTheoretical
Mizolastine - increases exposure
Miconazole is predicted to increase the exposure to antihistamines, non-sedating (mizolastine). Avoid.
Oral Benzodiazepines - increases exposure
Miconazole is predicted to increase the exposure to oral benzodiazepines (midazolam). Avoid.
Moderate (51)
Alfentanil - increases exposure
Miconazole is predicted to increase the exposure to opioids (alfentanil). Use with caution and adjust dose.
Alkylating Agents - increases concentration
Miconazole is predicted to increase the concentration of alkylating agents (busulfan). Use with caution and adjust dose.
Alprazolam - increases exposure
Miconazole is predicted to increase the exposure to benzodiazepines (alprazolam). Use with caution and adjust dose.
Amlodipine - increases exposure
Miconazole is predicted to increase the exposure to calcium channel blockers (amlodipine, felodipine, lacidipine, lercanidipine, nicardipine, nifedipine, nimodipine, verapamil). Use with caution and a
Antiarrhythmics - increases exposure
Miconazole is predicted to increase the exposure to antiarrhythmics (disopyramide). Use with caution and adjust dose.
Unknown (26)
Aminoglycosides - decreases exposure
Miconazole potentially decreases the exposure to aminoglycosides (tobramycin).
Aspirin - decreases concentration
Corticosteroids are predicted to decrease the concentration of aspirin (high-dose) and aspirin (high-dose) increases the risk of gastrointestinal bleeding when given with corticosteroids.
Choline Salicylate - decreases concentration
Corticosteroids are predicted to decrease the concentration of cholinesalicylate. Ciclesonide → see corticosteroids Ciclosporin → see TABLE 2 p. 1517 (nephrotoxicity), TABLE 16 p. 1521 (increased seru
Cobimetinib - increases exposure
Miconazoleispredictedtoincreasetheexposureto cobimetinib.rTheoretical
Corticosteroids - increases exposure
Cobicistat is predicted to increase the exposure to corticosteroids (beclometasone) (risk with beclometasone is likely to be lower than with other corticosteroids).
Data from BNF 85 (British National Formulary). This is not a substitute for professional medical advice. Matched via: exact
About miconazole
Miconazole is an antifungal medication used to treat fungal infections on the skin and in the mouth.
What it treats
- fungal infections of the skin
- oral thrush (fungal infection in the mouth)
How it works
It works by stopping the growth of fungi, helping to clear the infection.
Who it's for
This medication is for adults and children who have fungal infections.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
About mometasone
Mometasone is a corticosteroid used to reduce inflammation and treat various allergic and skin conditions.
What it treats
- allergic rhinitis (hay fever)
- asthma
- skin conditions like eczema and psoriasis
How it works
It works by reducing inflammation in the body, which helps relieve symptoms.
Who it's for
It is for people suffering from allergies, asthma, or certain skin problems.
Drug class
Corticosteroids
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
About nadifloxacin
Nadifloxacin is an antibiotic used to treat bacterial skin infections.
What it treats
- bacterial skin infections
- impetigo
- folliculitis
How it works
It works by killing the bacteria that cause the infection.
Who it's for
It is for people with skin infections caused by certain types of bacteria.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: Miconazole
BNF-referencedMiconazole is an azole antifungal agent utilized for the treatment of various fungal infections, particularly those caused by Candida species. It acts primarily by inhibiting the synthesis of ergosterol, a key component of fungal cell membranes, thereby compromising the integrity and function of the fungal cell. Miconazole can be administered topically, orally, or intravaginally, making it versatile for treating conditions such as oropharyngeal candidiasis, vaginal candidiasis, and superficial skin infections.
Indications
- Vaginal candidiasis
- Oropharyngeal candidiasis
- Vulvovaginal infections
- Superficial fungal infections
Dosage
Adults: For vaginal candidiasis, miconazole cream is typically applied twice daily, using 5 g inserted into the vagina for 7 days. For oropharyngeal candidiasis, the oral gel is usually administered as 2.5 mL four times a day.
Mechanism of action
Miconazole primarily acts through the inhibition of the CYP450 14α-lanosterol demethylase enzyme, leading to disrupted ergosterol production in fungal cell membranes. This disruption results in increased cell membrane permeability and leakage of essential cellular constituents. Additionally, miconazole inhibits fungal peroxidase and catalase, increasing the production of reactive oxygen species (ROS) which contribute to fungal cell death. Miconazole also elevates intracellular levels of farnesol, which disrupts quorum sensing in Candida, preventing the transition to more virulent forms.
Pharmacodynamics
Miconazole is predominantly applied topically, leading to minimal systemic absorption. Its primary adverse reactions are usually localized to hypersensitivity reactions, with the potential for anaphylaxis in rare cases. Patients using intravaginal miconazole are advised to avoid reliance on other contraceptive methods and not to use tampons simultaneously due to the risk of altered vaginal flora.
Pharmacokinetics
Miconazole is poorly absorbed when applied topically or intravaginally, resulting in low systemic exposure. The pharmacokinetics of miconazole can vary based on the route of administration, but systemic absorption is generally low, thus limiting systemic side effects and interactions. Miconazole is extensively metabolized in the liver, and its metabolites are excreted primarily through the urine.
Contra-indications
- Hypersensitivity to miconazole or any of its excipients
- Recent arterial thromboembolic disease (e.g. angina, myocardial infarction)
- Undiagnosed vaginal bleeding
- Oestrogen-dependent tumors (e.g. breast cancer in first-degree relatives)
- Acute porphyrias
- Severe diabetes (increased risk of heart disease)
Adverse effects
- Dysmenorrhoea
- Skin reactions
- Increased risk of gallbladder disease
- Migraine or migraine-like headaches
- Abdominal pain
- Dysuria
- Nausea
- Pelvic cramps
- Vaginal hemorrhage
- Angioedema
Interactions
- Miconazole + antihistamines (non-sedating): Severe (increases exposure)
- Miconazole + mizolastine: Severe (increases exposure)
- Miconazole + oral benzodiazepines: Severe (increases exposure)
- Miconazole + ergometrine: Severe (increases exposure)
- Miconazole + ergotamine: Severe (increases exposure)
- Miconazole + alkylating agents: Moderate (increases concentration)
- Miconazole + busulfan: Moderate (increases concentration)
- Miconazole + antiarrhythmics: Moderate (increases exposure)
- Miconazole + disopyramide: Moderate (increases exposure)
- Miconazole + benzodiazepines: Moderate (increases exposure)
Precautions
- Caution in patients with history of breast cancer
- Monitor breast status regularly in women on oestrogen therapy
- Risk of endometrial cancer with prolonged use of oestrogens
- Risk of ovarian cancer with long-term use of combined HRT
- Increased risk of venous thromboembolism in women using combined or oestrogen-only HRT
Pregnancy
Pregnant women may require a longer duration of treatment, usually about 7 days, to clear the infection. Caution is advised.
Breast-feeding
Manufacturer advises caution; no specific information available.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Clinical monograph: Mometasonefuroate
BNF-referencedMometasone furoate is a potent corticosteroid used primarily for the management of asthma, allergic rhinitis, and nasal polyps. It exhibits anti-inflammatory, antipruritic, and vasoconstrictive properties, making it effective in reducing airway inflammation and alleviating symptoms of nasal congestion. Mometasone furoate is typically administered via inhalation or as a nasal spray, allowing for targeted delivery and minimizing systemic side effects.
Indications
- Management of asthma in adults and adolescents not adequately controlled with inhaled corticosteroids and short-acting beta-2 agonists
- Allergic rhinitis
- Nasal polyps
Dosage
Children: For children aged 12-17 years, initially 400 micrograms daily in 1-2 divided doses, single dose to be inhaled in the evening, reduced to 200 micrograms once daily if control is maintained.
Adults: 1 inhalation once daily; dosage may be increased to 400 micrograms twice daily if necessary.
Mechanism of action
Mometasone furoate works by binding to glucocorticoid receptors, leading to the modulation of gene expression. This results in the inhibition of pro-inflammatory cytokines and chemokines, thereby reducing inflammation in the airways and nasal passages. It also inhibits the activation of inflammatory cells such as eosinophils and mast cells, contributing to its therapeutic effects.
Pharmacodynamics
As a corticosteroid, mometasone furoate exhibits significant anti-inflammatory effects, which are crucial in the management of asthma and allergic conditions. The drug reduces airway hyper-responsiveness and decreases mucus production, leading to improved airflow and decreased symptoms such as wheezing and shortness of breath. Its rapid onset of action is beneficial for acute symptom relief.
Pharmacokinetics
Mometasone furoate is well-absorbed when administered by inhalation or nasal spray. It undergoes extensive first-pass metabolism in the liver, resulting in low systemic bioavailability. The drug is primarily excreted via the feces, with a small percentage eliminated through the urine. The half-life of mometasone furoate is approximately 5.8 hours, allowing for once-daily dosing in many cases.
Adverse effects
- Candida infection
- Nasal ulceration
- Throat irritation
- Headache
- Cough
Interactions
- Corticosteroids
- Beta2 agonists
Precautions
- Use with caution in patients with active or quiescent tuberculosis infections
- Monitor for signs of infection
- Use in hepatic impairment requires caution
Pregnancy
Use only if potential benefit outweighs risk-limited information available.
Breast-feeding
Avoid-present in milk in animal studies.
Storage
Store below 30°C. Protect from light and moisture.
Formulations
- {'form': 'Inhalation powder', 'strength': '200 micrograms per dose', 'brand': 'Asmanex Twisthaler'}
- {'form': 'Aqueous nasal spray', 'strength': '50 micrograms per dose', 'brand': 'Flixonase'}
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Clinical monograph: mometasone
BNF-referencedMometasone is a synthetic corticosteroid that exhibits medium potency and is primarily used for its anti-inflammatory, antipruritic, and vasoconstrictive properties. It is effective in the management of various inflammatory conditions, such as asthma, allergic rhinitis, and skin disorders. Mometasone works by reducing inflammation and suppressing immune responses, providing relief from symptoms associated with these conditions.
Indications
- Asthma
- Allergic rhinitis
- Skin conditions (e.g., eczema, dermatitis)
Dosage
Children: Refer to the BNF for Children for appropriate paediatric dosing guidelines.
Adults: Refer to the specific BNF guidelines for adult dosing, which may vary based on the condition being treated.
Mechanism of action
Mometasone exerts its anti-inflammatory effects by crossing cell membranes and binding with high affinity to specific cytoplasmic glucocorticoid receptors. This interaction diminishes the release of leukocytic acid hydrolases, prevents macrophage accumulation at inflamed sites, interferes with leukocyte adhesion to capillary walls, reduces capillary membrane permeability, and inhibits the release of histamine and kinin. Additionally, mometasone inhibits the formation of scar tissue and acts through phospholipase A2 inhibitory proteins, known as lipocortins, which control the synthesis of potent inflammatory mediators like prostaglandins and leukotrienes.
Pharmacodynamics
Mometasone demonstrates medium potency as a corticosteroid, effectively reducing inflammation without significant systemic absorption due to extensive hepatic metabolism. Its local effects are favored over systemic effects, making it suitable for chronic conditions like asthma, where immediate symptom relief is not expected. The onset of action may take 1 to 2 weeks for maximum improvement in asthma symptoms following inhalation. Discontinuation of mometasone may allow for sustained asthma stability for several days.
Pharmacokinetics
Mometasone is extensively metabolized in the liver, resulting in a low systemic bioavailability. Its pharmacokinetic profile includes rapid absorption and distribution, with a half-life that supports once-daily dosing in many cases. The lack of active metabolites contributes to its safety profile, minimizing systemic effects while providing effective local action.
Interactions
- cobicistat+mometasone: Unknown (increases exposure)
- idelalisib+mometasone: Unknown (increases exposure)
- clarithromycin+mometasone: Unknown (increases exposure)
Pregnancy
Mometasone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
Caution should be exercised when administering mometasone to nursing mothers, as it is not known whether it is excreted in human milk.
Storage
Store at room temperature, away from light and moisture. Do not freeze.
Formulations
- Mometasone furoate nasal spray
- Mometasone furoate inhalation aerosol
- Mometasone furoate cream
- Mometasone furoate ointment
- Mometasone furoate lotion
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Clinical monograph: nadifloxacin
BNF-referencedNadifloxacin is a topical antibiotic belonging to the fluoroquinolone class, utilized primarily for the treatment of bacterial skin infections. It exhibits both antibacterial and anti-inflammatory properties, making it effective in managing conditions exacerbated by inflammation.
Indications
- Bacterial skin infections
- Folliculitis
- Impetigo
- Acne vulgaris
Dosage
Children: Refer to the BNF for Children for appropriate dosing in children.
Adults: Apply a thin layer to the affected area twice daily for up to 2 weeks.
Mechanism of action
The exact mechanism of action of nadifloxacin has not been fully elucidated, although it is known to inhibit bacterial DNA gyrase and topoisomerase IV, leading to disruption of DNA replication and transcription in susceptible bacteria.
Pharmacodynamics
Nadifloxacin has anti-inflammatory properties. It attenuated the release of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes, which contributes to its efficacy in treating inflammatory skin conditions.
Pharmacokinetics
Nadifloxacin is primarily administered topically, resulting in localized action at the site of application. Systemic absorption is minimal, leading to a lower risk of systemic side effects. The distribution, metabolism, and elimination specifics are not fully characterized, but its topical application limits systemic exposure.
Pregnancy
There are no adequate and well-controlled studies in pregnant women. Nadifloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
It is not known whether nadifloxacin is excreted in human milk. Caution should be exercised when nadifloxacin is administered to a nursing woman.
Storage
Store at room temperature, away from light and moisture. Keep out of reach of children.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: Miconazole
PubChem CID 4189Molecular formula: C18H14Cl4N2O
Mechanism of action
Miconazole is an azole antifungal used to treat a variety of conditions, including those caused by _Candida_ overgrowth. Unique among the azoles, miconazole is thought to act through three main mechanisms. The primary mechanism of action is through inhibition of the CYP450 14α-lanosterol demethylase enzyme, which results in altered ergosterol production and impaired cell membrane composition and permeability, which in turn leads to cation, phosphate, and low molecular weight protein leakage. In addition, miconazole inhibits fungal peroxidase and catalase while not affecting NADH oxidase activity, leading to increased production of reactive oxygen species (ROS). Increased intracellular ROS leads to downstream pleiotropic effects and eventual apoptosis. Lastly, likely as a result of lanosterol demethylation inhibition, miconazole causes a rise in intracellular levels of farnesol. This molecule participates in quorum sensing in _Candida_, preventing the transition from yeast to mycelial forms and thereby the formation of biofilms, which are more resistant to antibiotics. In addition, farnesol is an inhibitor of drug efflux ABC transporters, namely _Candida_ CaCdr1p and CaCdr2p, which may additionally contribute to increased effectiveness of azole drugs.
Pharmacodynamics
Miconazole is an azole antifungal that functions primarily through inhibition of a specific demethylase within the CYP450 complex. As miconazole is typically applied topically and is minimally absorbed into the systemic circulation following application, the majority of patient reactions are limited to hypersensitivity and cases of anaphylaxis. Patients using intravaginal miconazole products are advised not to rely on contraceptives to prevent pregnancy and sexually transmitted infections, as well as not to use tampons concurrently.
Biological pathways
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
Molecular reference: mometasone
PubChem CID 441335Molecular formula: C22H28Cl2O4
Mechanism of action
Unbound corticosteroids cross cell membranes and bind with high affinity to specific cytoplasmic receptors. Inflammation is decreased by diminishing the release of leukocytic acid hydrolases, prevention of macrophage accumulation at inflamed sites, interference with leukocyte adhesion to the capillary wall, reduction of capillary membrane permeability, reduction of complement components, inhibition of histamine and kinin release, and interference with the formation of scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A<sub>2</sub> inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Mometasone furoate has been shown in vitro to exhibit a binding affinity for the human glucocorticoid receptor which is approximately 12 times that of dexamethasone, 7 times that of triamcinolone acetonide, 5 times that of budesonide, and 1.5 times that of fluticasone.
Pharmacodynamics
Mometasone is a medium-potency synthetic corticosteroid with antiinflammatory, antipruritic, and vasoconstrictive properties. Studies in asthmatic patients have demonstrated that mometasone provides a favorable ratio of topical to systemic activity due to its primary local effect along with the extensive hepatic metabolism and the lack of active metabolites. Though effective for the treatment of asthma, glucocorticoids do not affect asthma symptoms immediately. Maximum improvement in symptoms following inhaled administration of mometasone furoate may not be achieved for 1 to 2 weeks or longer after starting treatment. When glucocorticoids are discontinued, asthma stability may persist for several days or longer. Mometasone has been shown in vitro to exhibit a binding affinity for the human glucocorticoid receptor which is approximately 12 times that of dexamethasone, 7 times that of triamcinolone acetonide, 5 times that of budesonide, and 1.5 times that of fluticasone. The clinical significance of these findings is unknown.
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
Molecular reference: nadifloxacin
PubChem CID 4410Molecular formula: C19H21FN2O4
Mechanism of action
The exact mechanism of action of nadifloxacin has not been fully elucidated.
Pharmacodynamics
Nadifloxacin has anti-inflammatory properties. It attenuated the release of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes.
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.
- BECLEM COMBINATION PRODUCT OINTMENT
- BECLOMIN 0.025%W/V , 2.000%W/V LOTION
- DACINAZOLE 2%W/W CREAM
- DAKTARIN 20MG/G ORAL GEL
- DERMACIN COMBINATION PRODUCT CREAM
- DERMIDEX 2%W/W CREAM
- CANDIFEM VAGINAL CREAM · Meyer Organics
- CANDIMALE-15 · Meyer Organics
- DACINAZOLE CREAM · Dawa
- DERMIDEX CREAM · Regal Pharmaceuticals
- DREZ-V GEL · Stedman Pharmaceuticals
- FUNGARIN · S Kant Healthcare
- ADVASONE SPRAY ( MOMETASONE FUMERATE 0.52%) · Biodeal Pharmaceuticals
- DAKTACORT 2% CREAM ( Miconazole/ Hydrocortisone 2%w/w/ 1%w/w) · Janssen Pharmaceutica
- DAKTARIN ORAL GEL · Janssen-Cilag
- DERMAV CREAM (Each tube contains Hydroquinone USP/ Tretinoin USP/ Mometasone furoate USP 2%w/v, 0.025%w/w, 0.10%w/w) · Mars Remedies
- DREZ-V GEL ( Miconazole Nitrate/ Metronidazol 2.0%w/v/ 1.0%w/v) · Stedman Pharmaceuticals
- ELICA OINTMENT · Jamjoom Pharmaceuticals