NAFTOL 10%W/V SOLUTION

Indications

• Tinea pedis (athlete's foot)
• Tinea cruris (jock itch)
• Tinea corporis (ringworm)
• Other superficial fungal infections

Dosage

Children: Refer to the BNF for Children for specific dosing recommendations.

Adults: Apply to the affected area twice daily for 2 to 4 weeks.

Mechanism of action

Tolnaftate is a topical fungicide. Though its exact mechanism is unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and stunt mycelial growth in susceptible organisms.

Pharmacodynamics

Tolnaftate is a synthetic over-the-counter antifungal agent that acts primarily on dermatophytes, causing morphological changes in fungal cells and inhibiting their growth.

Pharmacokinetics

Tolnaftate is applied topically, which limits its systemic absorption. The pharmacokinetics are not extensively detailed due to its topical application, but it is designed to act directly at the site of infection with minimal systemic exposure.

Pregnancy

There are no adequate and well-controlled studies in pregnant women. Use only if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

It is not known whether tolnaftate is excreted in human milk. Caution should be exercised when administered to a nursing woman.

Storage

Store in a cool, dry place away from direct sunlight. Keep out of reach of children.

Formulations

• Topical cream
• Topical powder
• Topical spray

Mechanism of action

Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.

Pharmacodynamics

Tolnaftate is a synthetic over-the-counter anti-fungal agent.