Naso B12
Methylcobalamine 5.000 mg/ml
What it does
Methylcobalamine is a form of vitamin B12 that helps in maintaining healthy nerve cells and supporting the production of red blood cells.
Commonly used for: Vitamin B12 deficiency, Peripheral neuropathy, Anemia
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Zambia Medicines Regulatory Authority · fetched 2026-04-14 13:59:51 · updated 2026-09-17 03:36:22
About this medicine
Methylcobalamine is a form of vitamin B12 that helps in maintaining healthy nerve cells and supporting the production of red blood cells.
What it treats
- Vitamin B12 deficiency
- Peripheral neuropathy
- Anemia
How it works
It works by providing essential nutrients that help in the proper functioning of nerves and the formation of blood cells.
Who it's for
It is suitable for people who have low levels of vitamin B12, which may occur due to certain health conditions or dietary deficiencies.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: methylcobalamine
Methylcobalamin is a bioactive form of vitamin B12 that plays a critical role in various biological processes, particularly in the functioning of the nervous system and the formation of red blood cells. It is involved in the synthesis of methionine from homocysteine, which is crucial for DNA synthesis and neuronal health. Methylcobalamin is often used as a dietary supplement and in the treatment of vitamin B12 deficiency-related conditions, including peripheral neuropathy and megaloblastic anemia.
Indications
- Vitamin B12 deficiency
- Peripheral neuropathy
- Megaloblastic anemia
- Homocystinuria
Dosage
Children: Refer to the BNF for Children for appropriate paediatric dosing information.
Adults: Refer to the BNF for specific dosing recommendations based on the indication.
Mechanism of action
Methylcobalamin functions as a coenzyme in the conversion of homocysteine to methionine, facilitating the synthesis of S-adenosylmethionine (SAMe). SAMe is a critical methyl donor in numerous biochemical reactions, including the methylation of DNA and proteins. Additionally, methylcobalamin is essential for the regeneration of folate, impacting DNA synthesis and repair. It also promotes nerve regeneration and repair, making it beneficial in conditions involving nerve damage.
Pharmacodynamics
Methylcobalamin exhibits neuroprotective properties by enhancing nerve growth factor (NGF) synthesis and supporting neuronal survival. It aids in the reduction of neuropathic pain and may improve neurological function in patients with vitamin B12 deficiency. The compound's role in methylation processes further influences cellular metabolism, contributing to overall health.
Pharmacokinetics
Methylcobalamin is absorbed in the intestines, and its bioavailability can be influenced by the presence of intrinsic factor, which is necessary for vitamin B12 absorption. Once absorbed, it is distributed throughout the body, particularly in the liver, kidneys, and nervous tissue. The elimination half-life of methylcobalamin is variable, and the compound is primarily excreted in the urine as metabolites. Storage and transport within the body are facilitated by transcobalamin II, a specific transport protein.
Adverse effects
- Headache
- Nausea
- Diarrhea
- Dizziness
- Rash
- Itching
Interactions
- Alcohol may decrease the absorption of methylcobalamin
- Certain medications that affect vitamin B12 levels
Precautions
- Patients with Leber's disease should use with caution
- Monitor for signs of hypersensitivity
Pregnancy
Methylcobalamin is generally considered safe during pregnancy as it is a form of vitamin B12, but consult a healthcare provider for personalized advice.
Breast-feeding
Methylcobalamin is excreted in breast milk, but is considered safe for use during breastfeeding; consult a healthcare provider for personalized advice.
Storage
Store in a tightly closed container at room temperature, away from moisture and heat.
Formulations
- Oral tablets
- Sublingual tablets
- Injectable solution
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
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