NAXACOR CREAM
NADIFLOXACIN
What it does
Nadifloxacin is an antibiotic used to treat bacterial skin infections.
Commonly used for: bacterial skin infections, impetigo, folliculitis
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 19:35:58 · updated 2026-09-25 02:12:09
About this medicine
Nadifloxacin is an antibiotic used to treat bacterial skin infections.
What it treats
- bacterial skin infections
- impetigo
- folliculitis
How it works
It works by killing the bacteria that cause the infection.
Who it's for
It is for people with skin infections caused by certain types of bacteria.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: nadifloxacin
BNF-referencedNadifloxacin is a topical antibiotic belonging to the fluoroquinolone class, utilized primarily for the treatment of bacterial skin infections. It exhibits both antibacterial and anti-inflammatory properties, making it effective in managing conditions exacerbated by inflammation.
Indications
- Bacterial skin infections
- Folliculitis
- Impetigo
- Acne vulgaris
Dosage
Children: Refer to the BNF for Children for appropriate dosing in children.
Adults: Apply a thin layer to the affected area twice daily for up to 2 weeks.
Mechanism of action
The exact mechanism of action of nadifloxacin has not been fully elucidated, although it is known to inhibit bacterial DNA gyrase and topoisomerase IV, leading to disruption of DNA replication and transcription in susceptible bacteria.
Pharmacodynamics
Nadifloxacin has anti-inflammatory properties. It attenuated the release of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes, which contributes to its efficacy in treating inflammatory skin conditions.
Pharmacokinetics
Nadifloxacin is primarily administered topically, resulting in localized action at the site of application. Systemic absorption is minimal, leading to a lower risk of systemic side effects. The distribution, metabolism, and elimination specifics are not fully characterized, but its topical application limits systemic exposure.
Pregnancy
There are no adequate and well-controlled studies in pregnant women. Nadifloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
It is not known whether nadifloxacin is excreted in human milk. Caution should be exercised when nadifloxacin is administered to a nursing woman.
Storage
Store at room temperature, away from light and moisture. Keep out of reach of children.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: nadifloxacin
PubChem CID 4410Molecular formula: C19H21FN2O4
Mechanism of action
The exact mechanism of action of nadifloxacin has not been fully elucidated.
Pharmacodynamics
Nadifloxacin has anti-inflammatory properties. It attenuated the release of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes.
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.