NEOPRED OPHTHALMIC EMULSION
DIFLUPREDNATE INN
What it does
Difluprednate is a type of medicine used to reduce inflammation in the eye.
Commonly used for: eye inflammation, uveitis
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
Ask about this medicine
Answers come only from this medicine's registration record, BNF monograph and interaction data - not medical advice.
Hard to find? We help patients in Kenya source rare medicines. We don't sell or dispense medicines - licensed pharmacies do.
Source this medicineRegistration & product details
Source: Pharmacy and Poisons Board · fetched 2026-07-06 02:01:37 · updated 2026-09-25 02:06:39
About this medicine
Difluprednate is a type of medicine used to reduce inflammation in the eye.
What it treats
- eye inflammation
- uveitis
How it works
It works by reducing swelling and redness in the eye.
Who it's for
This medicine is for adults and children who have specific eye conditions causing inflammation.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: difluprednate
BNF-referencedDifluprednate is a synthetic corticosteroid primarily used for its anti-inflammatory properties in ocular applications. It is effective in reducing inflammation and pain associated with eye surgery and other ocular conditions.
Indications
- Postoperative inflammation
- Ocular inflammation
- Uveitis
Dosage
Children: Refer to the BNF for Children for specific dosing guidelines.
Adults: Refer to the BNF for specific dosing guidelines.
Mechanism of action
Corticosteroids, such as difluprednate, exert their effects by inducing the synthesis of phospholipase A2 inhibitory proteins known as lipocortins. These proteins modulate the biosynthesis of inflammatory mediators including prostaglandins and leukotrienes by inhibiting the release of arachidonic acid, a common precursor released from membrane phospholipids by phospholipase A2.
Pharmacodynamics
Difluprednate functions as an anti-inflammatory corticosteroid, which helps to alleviate inflammation and discomfort in the ocular region, particularly following surgical procedures.
Pharmacokinetics
Difluprednate is absorbed topically when administered as an ophthalmic solution. Its pharmacokinetics, including onset of action and duration, may vary based on the formulation and individual patient factors. The systemic absorption is minimal due to its local application, leading to a more favorable side effect profile compared to systemic corticosteroids.
Pregnancy
Difluprednate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
Caution should be exercised when administering difluprednate to a breastfeeding mother.
Storage
Store at room temperature, away from light and moisture. Do not freeze.
Formulations
- Ophthalmic emulsion
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: difluprednate
PubChem CID 443936Molecular formula: C27H34F2O7
Mechanism of action
Corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins (lipocortins). It is postulated that these proteins control the biosynthesis of potent mediators of infammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
Pharmacodynamics
Difluprednate is a corticosteroid used as an anti-inflammatory steroidal drug used primarily in ocular surgery.
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.