NODIAR 3G
DIOSMECTITE
What it does
Diosmectite is a natural clay that helps to relieve diarrhea by absorbing excess fluid in the intestines.
Commonly used for: diarrhea, gastroenteritis
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 20:08:30 · updated 2026-08-03 04:08:46
About this medicine
Diosmectite is a natural clay that helps to relieve diarrhea by absorbing excess fluid in the intestines.
What it treats
- diarrhea
- gastroenteritis
How it works
It works by binding to harmful substances in the gut and reducing the fluid in the stool.
Who it's for
It is suitable for adults and children experiencing diarrhea.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: diosmectite
BNF-referencedDiosmectite is a naturally occurring clay mineral, primarily used in the management of acute and chronic diarrhea, including diarrhea associated with infectious diseases and in the treatment of gastrointestinal disorders. It is known for its ability to adsorb toxins and pathogens in the gastrointestinal tract, thereby providing a protective barrier against irritation and inflammation.
Indications
- Acute diarrhea
- Chronic diarrhea
- Diarrhea associated with infectious diseases
- Gastrointestinal disorders
Dosage
Children: Refer to the BNF for Children for specific dosing guidelines.
Adults: Refer to the BNF for specific dosing guidelines.
Mechanism of action
The exact mechanism of action of diosmectite is not fully understood. However, it is believed to act by adsorbing bacteria, viruses, and toxins in the gastrointestinal tract, which helps to reduce inflammation and protect the intestinal mucosa. Studies suggest that diosmectite may also inhibit the activity of human leukocyte elastase, an enzyme that plays a role in the immune response, thus potentially enhancing its protective effects.
Pharmacodynamics
Diosmectite acts primarily by forming a viscous gel that coats the intestinal lining, improving mucosal protection and reducing permeability to harmful substances. This gel-like consistency helps to stabilize the stool consistency in diarrhea and can help alleviate symptoms associated with gastrointestinal disturbances.
Pharmacokinetics
Diosmectite is not absorbed systemically; it acts locally within the gastrointestinal tract. After oral administration, it passes through the digestive system without undergoing significant metabolic alteration. Its action is primarily due to its physical properties as a clay mineral that can adsorb various substances.
Pregnancy
Diosmectite is generally considered safe for use during pregnancy, but it is advisable to consult a healthcare professional before use.
Breast-feeding
Diosmectite is considered safe during breastfeeding, but nursing mothers should consult with a healthcare provider.
Storage
Store in a cool, dry place, away from direct sunlight.
Formulations
- Powder for oral suspension
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: diosmectite
PubChem CID 71586775Molecular formula: Al2H2O12Si4
Mechanism of action
The mechanism by which bentonite increases susceptibility is unknown. /Investigators/ however, postulated that enzyme inhibition by bentonite may be a factor, based on their in vitro observation that a low concentration of bentonite can totally suppress the activity of human leukocyte elastase, an enzyme important in the destruction of microorganisms phagocytized by neutrophils.
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.