Norbrook Milking Salve

Indications

• Bacterial infections
• Fungal infections
• Topical antiseptic for skin infections

Dosage

Children: Refer to the BNF for Children for paediatric dosing guidelines.

Adults: Refer to the BNF for specific dosing information based on the condition being treated.

Mechanism of action

Dichlorophen exerts its antimicrobial effects by disrupting the integrity of microbial cell membranes and inhibiting essential cellular processes. This leads to cell lysis and death in susceptible organisms. The compound's action is primarily due to its ability to denature proteins and interfere with metabolic pathways critical for microbial survival.

Pharmacodynamics

Dichlorophen demonstrates a broad spectrum of antimicrobial activity, effective against various bacteria, fungi, and some viruses. Its potency is partly attributed to its lipophilic nature, allowing it to penetrate microbial membranes easily. The drug's efficacy can vary based on the concentration used and the specific microbial strains being targeted.

Pharmacokinetics

Dichlorophen is absorbed through the gastrointestinal tract and distributed throughout the body. It undergoes hepatic metabolism, primarily through conjugation and oxidation, and is eliminated via renal pathways. The drug's half-life and clearance rates can vary depending on individual patient factors, including age, liver function, and renal status.

Contra-indications

• Hypersensitivity to dichlorophen or any of its components
• History of liver disease
• Severe renal impairment

Adverse effects

• Nausea
• Vomiting
• Abdominal pain
• Diarrhoea
• Rash
• Headache
• Dizziness
• Hepatotoxicity

Interactions

• May enhance the effects of anticoagulants
• Potential interaction with other hepatotoxic drugs
• May alter the metabolism of other medications metabolized by the liver

Precautions

• Use with caution in patients with liver or kidney disease
• Monitor liver function during prolonged therapy
• Discontinue if signs of hepatic dysfunction occur
• Not recommended for use in children unless specifically prescribed

Pregnancy

There is limited information on the safety of dichlorophen during pregnancy. Use only if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

It is not known if dichlorophen is excreted in human milk. Caution should be exercised when administering to nursing mothers.

Storage

Store in a cool, dry place away from light. Keep out of reach of children.

Formulations

• Tablets
• Oral suspension