OFLOMAC 200

Indications

• Acute bacterial sinusitis
• Chronic bronchitis exacerbations
• Community-acquired pneumonia
• Urinary tract infections
• Skin and soft tissue infections
• Bone and joint infections

Dosage

Children: Refer to the BNF for Children for appropriate dosing information based on the child's age and weight.

Adults: Refer to the relevant guidelines or BNF for specific dosing recommendations based on the type and severity of infection.

Mechanism of action

Oflomac exerts its antibacterial effects by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for DNA replication, transcription, and repair. This inhibition prevents the supercoiling of DNA, leading to bacterial cell death.

Pharmacodynamics

The pharmacodynamics of oflomac involve concentration-dependent killing, where higher drug concentrations correlate with greater antibacterial activity. The time above the minimum inhibitory concentration (MIC) is a crucial determinant of its efficacy, highlighting the importance of achieving adequate drug levels in the body to effectively combat infections.

Pharmacokinetics

Oflomac is well-absorbed from the gastrointestinal tract, with a bioavailability that is typically high. It is widely distributed throughout the body, including in tissues and fluids such as lungs and urine. The drug undergoes hepatic metabolism and is primarily eliminated via the kidneys. Its half-life allows for once or twice-daily dosing, depending on the severity of the infection.

Contra-indications

• Hypersensitivity to ofloxacin or any other quinolone antibiotics
• History of tendon disorders related to fluoroquinolone use
• Concurrent use of tizanidine

Adverse effects

• Nausea
• Diarrhea
• Headache
• Dizziness
• Insomnia
• Tendon rupture
• QT interval prolongation
• Photosensitivity

Interactions

• Antacids containing magnesium or aluminum may reduce absorption
• Cation-containing products (e.g., iron, zinc) can interfere with efficacy
• Warfarin may have increased anticoagulant effect when co-administered
• Caffeine metabolism may be inhibited leading to increased effects

Precautions

• Use with caution in patients with a history of seizures
• Monitor for signs of tendonitis or tendon rupture
• Avoid in patients with myasthenia gravis due to potential exacerbation
• Assess renal function, dosage adjustment may be necessary

Pregnancy

Oflomac is classified as pregnancy category C. It should be used only if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

Oflomac is excreted in breast milk. Caution should be exercised when administering to nursing mothers.

Storage

Store at room temperature, away from excess heat and moisture. Keep out of reach of children.

Formulations

• Oflomac 200 mg tablet
• Oflomac 400 mg tablet
• Oflomac 100 mg/ml oral solution
• Oflomac 0.3% eye drops