ONAPAT EYE DROPS
OLAPATADINE HYDROCHLORIDE
What it does
Olapatadine is a medication used to relieve allergy symptoms such as itchy eyes.
Commonly used for: allergic conjunctivitis, eye allergies
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 19:20:05 · updated 2026-11-03 02:07:56
About this medicine
Olapatadine is a medication used to relieve allergy symptoms such as itchy eyes.
What it treats
- allergic conjunctivitis
- eye allergies
How it works
Olapatadine works by blocking certain substances in the body that cause allergic reactions, helping to reduce symptoms like itching and redness in the eyes.
Who it's for
This medicine is for people suffering from eye allergies.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: olapatadine
Olapatadine is a second-generation antihistamine primarily used for the treatment of allergic conjunctivitis and allergic rhinitis. It works by blocking the action of histamine at the H1 receptor, thereby alleviating symptoms such as itching, redness, and swelling associated with allergic reactions.
Indications
- Allergic conjunctivitis
- Allergic rhinitis
Dosage
Children: Refer to specific guidelines for pediatric dosing, as it may differ from adult dosing and is contingent upon the specific formulation used.
Adults: Refer to specific guidelines for dosing based on the condition being treated, as dosing may vary between formulations and routes of administration.
Mechanism of action
Olapatadine is a selective H1 antagonist that inhibits the binding of histamine to its receptors. This action reduces the symptoms of allergic reactions. Additionally, olapatadine has been shown to stabilize mast cells, which decreases the release of histamine and other inflammatory mediators.
Pharmacodynamics
Olapatadine exhibits a high affinity for H1 receptors, leading to a decrease in vascular permeability and a reduction in allergic response. Its dual action not only helps relieve immediate allergic symptoms but also contributes to a longer-lasting therapeutic effect by preventing mast cell degranulation.
Pharmacokinetics
Olapatadine is well-absorbed after topical administration. It has a bioavailability that supports its efficacy in treating allergic conditions. The drug undergoes hepatic metabolism, primarily via the cytochrome P450 system, and is excreted mainly in the urine. Its half-life allows for once or twice daily dosing in clinical settings.
Adverse effects
- Headache
- Somnolence
- Dry mouth
- Nausea
- Fatigue
- Dizziness
Precautions
- Use with caution in patients with renal impairment
- Monitor for exacerbation of asthma or other respiratory conditions
- Consider potential for sedation when driving or operating machinery
Pregnancy
Olopatadine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus, as there are no adequate and well-controlled studies in pregnant women.
Breast-feeding
It is not known whether olopatadine is excreted in human milk. Caution should be exercised when administering to nursing women.
Storage
Store at room temperature, away from light and moisture. Keep out of reach of children.
Formulations
- Ophthalmic solution
- Oral tablets
- Intranasal spray
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.