What it does
Ondasterob is a medication used to help prevent nausea and vomiting, especially after surgery or during chemotherapy.
Commonly used for: nausea after surgery, vomiting during chemotherapy
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 20:20:56 · updated 2026-07-26 09:20:14
About this medicine
Ondasterob is a medication used to help prevent nausea and vomiting, especially after surgery or during chemotherapy.
What it treats
- nausea after surgery
- vomiting during chemotherapy
How it works
It works by blocking signals in the brain that cause nausea and vomiting.
Who it's for
This medication is suitable for adults and children who are experiencing nausea and vomiting.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: ondasterob
Ondansetron is a selective serotonin 5-HT3 receptor antagonist. It is primarily used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. Ondansetron works by blocking the action of serotonin, a natural substance in the body that can cause nausea and vomiting.
Indications
- Nausea and vomiting associated with chemotherapy
- Nausea and vomiting associated with radiotherapy
- Postoperative nausea and vomiting
Dosage
Children: Refer to BNF for Children for specific dosing guidelines based on age and weight.
Adults: Refer to BNF for specific dosing guidelines based on clinical scenario and patient factors.
Mechanism of action
Ondansetron selectively antagonizes the 5-HT3 receptors in the central nervous system and the gastrointestinal tract. This action prevents the binding of serotonin, which is released from the enterochromaffin cells of the gastrointestinal tract. The blockade of these receptors inhibits the vagal stimulation that triggers the vomiting reflex.
Pharmacodynamics
Ondansetron has a high affinity for 5-HT3 receptors, which are involved in the vomiting reflex. By blocking these receptors, ondansetron effectively reduces the incidence and severity of nausea and vomiting. The onset of action is typically within 30 minutes, and its antiemetic effects can last up to 12 hours.
Pharmacokinetics
Ondansetron is well absorbed after oral administration, with a bioavailability of approximately 60% to 70%. It is extensively metabolized in the liver by cytochrome P450 enzymes, primarily CYP3A4, CYP2D6, and CYP1A2. The elimination half-life is about 3 to 6 hours, and it is excreted mainly in the urine as metabolites. The drug's clearance may be affected by age, liver function, and the presence of other medications.
Pregnancy
The safety of ondasterob during pregnancy has not been established. Use only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
It is not known whether ondasterob is excreted in human milk. Caution should be exercised when administering to nursing mothers.
Storage
Store at room temperature, away from light and moisture. Keep out of reach of children.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.