Registered Malawi · PMRA

ORALDINE 15MG/5ML LIOUID

HEXETIDINE

PMPB/PL48/26 LIOUID alimentary tract and metabolism INN generic

What it does

Hexetidine is an antiseptic used to help reduce germs in the mouth and throat. It is often found in mouthwashes and throat gargles.

Commonly used for: sore throat, mouth ulcers, bad breath, gingivitis

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Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.

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Registration & product details

Registration no.
PMPB/PL48/26
Registration date
05/02/2001
Expiry date
30/03/1996
Status
Registered
Active ingredient
HEXETIDINE
Dosage form
LIOUID
Strength
-
Pack size
-
Therapeutic class
-
ATC class (WHO)
A01AB - Antiinfectives and antiseptics for local oral treatment
Drug group
ALIMENTARY TRACT AND METABOLISM
RxNorm RxCUI
5301
Manufacturer / MAH
-
Applicant / LTR
-
Country of origin
-

Source: Pharmacy and Medicines Regulatory Authority · fetched 2026-04-21 17:37:44 · updated 2026-09-22 04:33:04

Disclaimer: This information is sourced from Pharmacy and Medicines Regulatory Authority (Malawi). Always consult a qualified healthcare professional before using any medication.

About this medicine

Hexetidine is an antiseptic used to help reduce germs in the mouth and throat. It is often found in mouthwashes and throat gargles.

What it treats

  • sore throat
  • mouth ulcers
  • bad breath
  • gingivitis

How it works

Hexetidine works by killing germs and bacteria in the mouth and throat, helping to prevent infections and soothe irritation.

Who it's for

Hexetidine is suitable for adults and children over the age of 6, especially those experiencing oral or throat discomfort.

AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.

Clinical monograph: Hexetidine

BNF-referenced

Hexetidine is a topical antiseptic and antimicrobial agent used primarily for oral hygiene. It is effective against bacteria and fungi, making it beneficial in managing conditions such as gingivitis, oral candidiasis, and aphthous ulcers. Hexetidine works by disrupting the microbial cell membrane, which contributes to its antibacterial properties.

Indications

  • Oral hygiene
  • Gingivitis
  • Oral candidiasis
  • Management of aphthous ulcers

Dosage

Children: Child 12–17 years: Rinse or gargle 15 mL 2–3 times a day. Child: Apply 1–2 times a day to affected areas, to be used undiluted.

Adults: Rinse or gargle 15 mL 2–3 times a day, to be used undiluted.

Mechanism of action

Hexetidine exhibits its antimicrobial activity by disrupting the cell membrane of bacteria, leading to cell lysis and death. It also possesses antifungal properties, acting against yeast such as Candida species. The precise biochemical pathways involved include the alteration of microbial membrane permeability and inhibition of metabolic processes essential for microbial survival.

Pharmacodynamics

Hexetidine has a broad spectrum of activity against various microorganisms, including Gram-positive and Gram-negative bacteria, as well as fungi. Its effectiveness in reducing plaque formation and controlling oral infections enhances oral hygiene and prevents dental diseases. The drug's action is typically localized, with minimal systemic absorption.

Pharmacokinetics

Hexetidine is primarily applied topically and has limited systemic absorption when used as directed in mouthwash or dental gel formulations. Its localized action in the oral cavity allows for effective concentration at the site of infection without significant systemic effects. The pharmacokinetic profile indicates a rapid onset of action, with effects lasting for several hours post-application.

Adverse effects

  • Dry mouth
  • Hypersensitivity
  • Taste altered
  • Tongue discolouration
  • Tooth discolouration

Interactions

  • May be incompatible with some ingredients in toothpaste; rinse mouth thoroughly with water between using toothpaste and hexetidine-containing product.

Precautions

  • Discontinue treatment if desquamation occurs with mucosal irritation.

Pregnancy

There are no adequate data from the use of hexetidine in pregnant women. Caution is advised.

Breast-feeding

It is not known whether hexetidine is excreted in human milk. Caution is advised.

Storage

Store below 25°C. Keep out of reach of children.

Formulations

  • Hexetidine mouthwash 0.1% (1 mg per 1 mL)
  • Hexetidine dental gel 1%
BNF 85 (British National Formulary) p.1349 BNF for Children 2019-2020 p.750 PubChem / pathway

AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.

Molecular reference: Hexetidine

PubChem CID 3607

Molecular formula: C21H45N3

Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.

This drug in other countries

The same active ingredient registered across other registries we cover - including different brands.

Kenya 1 product