What it does
Diprostone is a medication used to help with certain childbirth processes.
Commonly used for: inducing labor, preparing the cervix for delivery
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 21:47:38 · updated 2026-03-23 04:32:49
About this medicine
Diprostone is a medication used to help with certain childbirth processes.
What it treats
- inducing labor
- preparing the cervix for delivery
How it works
Diprostone helps to soften and open the cervix, making it easier for a woman to give birth.
Who it's for
This medication is for pregnant women who need assistance with labor.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: diprostone
Diprostone is a synthetic prostaglandin analog used primarily in obstetrics for its ability to induce labor and facilitate cervical ripening. It is administered locally to the cervix and acts by mimicking the natural prostaglandins that promote uterine contractions and soften the cervix, making it suitable for childbirth.
Indications
- Cervical ripening in pregnant women at term
- Induction of labor
Dosage
Children: Not applicable or referenced.
Adults: Refer to the BNF for specific dosing guidelines.
Mechanism of action
Diprostone exerts its effects by binding to prostaglandin receptors, leading to an increase in intracellular calcium levels and enhanced myometrial contractility. This action promotes cervical dilation and effacement, facilitating the onset of labor.
Pharmacodynamics
As a prostaglandin E2 analog, diprostone influences smooth muscle relaxation and contraction. Its effects are mediated through the activation of specific G-protein coupled receptors, leading to changes in calcium ion concentration within uterine and cervical tissues. This not only aids in cervical ripening but also promotes effective uterine contractions during labor.
Pharmacokinetics
Diprostone is rapidly absorbed at the site of administration. Its bioavailability, distribution, metabolism, and excretion profiles are consistent with those of other prostaglandins. The onset of action occurs within hours, and its effects may last for several hours depending on the dose and individual patient response. Metabolism primarily occurs in the liver, with renal excretion of metabolites.
Contra-indications
- Hypersensitivity to diprostone or any of its components
- Active vaginal bleeding
- History of uterine surgery including cesarean delivery
- Multiple gestation (e.g., twins, triplets)
Adverse effects
- Uterine hyperstimulation
- Vaginal bleeding
- Fetal heart rate abnormalities
- Infection
- Nausea and vomiting
- Diarrhea
- Headache
Interactions
- Oxytocin may enhance the uterine stimulation effects of diprostone
- Other uterotonics may increase the risk of uterine hyperstimulation
Precautions
- Use with caution in patients with a history of uterine hypertonicity
- Monitor fetal heart rate and uterine activity closely during administration
- Consider potential risks in patients with cardiovascular disease or other significant comorbidities
Pregnancy
Diprostone is used for cervical ripening and induction of labor in pregnant women.
Breast-feeding
It is not known whether diprostone is excreted in human milk. Caution should be exercised when administering to nursing mothers.
Storage
Store at room temperature, away from moisture and heat, and protect from light.
Formulations
- Vaginal insert (e.g., dinoprostone controlled-release insert)
- Gel for intracervical use
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.