Pyrotropy Injection
Gycopyrrolate USP 0.2mg/ml
What it does
Glycopyrrolate is a medication that reduces secretions in the body, such as saliva and sweat. It is often used to help manage certain medical conditions.
Commonly used for: excessive sweating (hyperhidrosis), muscle spasms (muscle spasticity), pre-operative preparation to reduce saliva
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Zambia Medicines Regulatory Authority · fetched 2026-03-11 23:59:35 · updated 2026-07-13 04:24:48
About this medicine
Glycopyrrolate is a medication that reduces secretions in the body, such as saliva and sweat. It is often used to help manage certain medical conditions.
What it treats
- excessive sweating (hyperhidrosis)
- muscle spasms (muscle spasticity)
- pre-operative preparation to reduce saliva
How it works
Glycopyrrolate works by blocking certain nerve signals that cause the body to produce too much fluid.
Who it's for
This medication is suitable for adults and children who need help managing excessive secretions or muscle spasms.
Cautions
- • May not be suitable for individuals with certain medical conditions, such as glaucoma or urinary retention.
- • Use with caution in elderly patients or those with heart problems.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: gycopyrrolate
Glycopyrrolate is an anticholinergic medication primarily used to reduce salivation and secretions in surgical settings, as well as to manage peptic ulcers and certain gastrointestinal disorders. It acts by blocking the action of acetylcholine on muscarinic receptors, leading to decreased glandular secretions and relaxation of smooth muscles.
Indications
- Reduction of salivation and secretions during surgery
- Management of peptic ulcers
- Treatment of gastrointestinal disorders, including irritable bowel syndrome
- As an adjunct to anesthesia to prevent bradycardia
- Management of chronic obstructive pulmonary disease (COPD) as a bronchodilator
Dosage
Children: Refer to BNF for Children for specific dosing guidance.
Adults: Refer to BNF for specific dosing guidance.
Mechanism of action
Glycopyrrolate selectively inhibits the action of acetylcholine at muscarinic receptors in the peripheral nervous system. This blockade results in decreased secretions from salivary and sweat glands, as well as a reduction in gastrointestinal motility.
Pharmacodynamics
The drug exhibits dose-dependent effects on the muscarinic receptors, leading to reduced saliva production, decreased gastric acid secretion, and increased heart rate due to its vagolytic properties. Its onset of action is typically within 30 minutes when administered parenterally, with peak effects occurring within 1 hour. The duration of action can last for several hours, depending on the route of administration.
Pharmacokinetics
Glycopyrrolate is well absorbed following parenteral administration, with a bioavailability that can vary based on the route. It is extensively distributed throughout the body, including the central nervous system, although it has limited penetration due to its quaternary ammonium structure. Glycopyrrolate undergoes hepatic metabolism and is excreted primarily in the urine as unchanged drug and metabolites. The half-life ranges from 1 to 2 hours, but this can be prolonged in patients with renal impairment.
Contra-indications
- Hypersensitivity to glycopyrrolate or any of its components
- Angle-closure glaucoma
- Myasthenia gravis
- Severe ulcerative colitis
- Tachycardia
- Obstructive uropathy
Adverse effects
- Dry mouth
- Constipation
- Urinary retention
- Blurred vision
- Dizziness
- Tachycardia
- Nausea
- Vomiting
- Headache
Interactions
- Anticholinergic agents
- Antihistamines
- Tricyclic antidepressants
- Muscle relaxants
- Potassium channel blockers
Precautions
- Use with caution in patients with cardiovascular disease
- Monitor for signs of urinary retention
- Caution in elderly patients due to increased risk of adverse effects
- Be cautious in patients with gastrointestinal obstructions
Pregnancy
Glycopyrrolate is classified as a category C drug. Risk cannot be ruled out; use only if clearly needed.
Breast-feeding
It is unknown if glycopyrrolate is excreted in human milk; caution is advised.
Storage
Store at room temperature, away from moisture and heat. Keep out of reach of children.
Formulations
- Oral tablets
- Injection solution
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.
- ADRENALINE INJ 1MG/ML 1ML · Nairobi Pharmaceuticals
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- ATRAPURE 2.5ML INJECTION · Nairobi Enterprises
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- ATROPINE · Reddys Pharma
- ATROPINE SULPHATE INJ. 0.6MG/ML 1ML · Nairobi Pharmaceuticals