Ramicloz 900
tetramisole HCl 450mg and Oxycloxanide 450mg
What it does
Oxycloxanide is a medication used to treat certain parasitic infections in animals. It is not commonly used in humans.
Commonly used for: parasitic infections, helminthiasis
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Zambia Medicines Regulatory Authority · fetched 2026-04-20 05:17:01 · updated 2026-09-17 03:40:02
About oxycloxanide
Oxycloxanide is a medication used to treat certain parasitic infections in animals. It is not commonly used in humans.
What it treats
- parasitic infections
- helminthiasis
How it works
Oxycloxanide works by killing parasites, helping to clear the infection.
Who it's for
This medication is mainly for use in veterinary medicine, not for human treatment.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
About tetramisole
Tetramisole is a medication used to treat certain infections and conditions caused by parasites.
What it treats
- worm infections (helminthiasis)
- certain types of parasitic infections
How it works
Tetramisole helps to kill parasites in the body, allowing the immune system to eliminate them more effectively.
Who it's for
This medication is typically given to people with parasitic infections, especially in children and adults who are at risk.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: oxycloxanide
Oxycloxanide is an anthelmintic agent primarily used in veterinary medicine, particularly for the treatment of nematode and trematode infections in livestock. It is classified as a benzimidazole derivative, which works by inhibiting the metabolism of parasites and disrupting their energy production. Oxycloxanide is not commonly used in human medicine but may have potential applications in certain parasitic infections.
Indications
- Nematode infections
- Trematode infections
- Parasitic infections in livestock
Dosage
Children: Refer to specific guidelines or veterinary protocols for appropriate dosing information.
Adults: Refer to specific guidelines or veterinary protocols for appropriate dosing information.
Mechanism of action
Oxycloxanide exerts its action by binding to the β-tubulin of the parasite, leading to the inhibition of microtubule formation. This disrupts essential cellular processes such as cell division and intracellular transport, ultimately resulting in the death of the parasite. Additionally, it may interfere with the energy metabolism of the parasite by affecting mitochondrial function.
Pharmacodynamics
The pharmacodynamic profile of oxycloxanide is characterized by its broad-spectrum activity against various helminths. It exhibits a high affinity for the parasite's microtubules, which is critical for its anthelmintic effect. The drug's efficacy is influenced by factors such as the type of parasite, dosage, and duration of exposure.
Pharmacokinetics
Oxycloxanide is absorbed following oral administration, with peak plasma concentrations reached within a few hours. It undergoes hepatic metabolism, and its metabolites are primarily excreted via the urine and feces. The half-life of oxycloxanide varies depending on the species being treated, but it is generally considered to have a moderate elimination rate.
Pregnancy
There is limited data on the safety of oxycloxanide during pregnancy. It should only be used if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
It is not known whether oxycloxanide is excreted in human milk. Caution should be exercised when administering to nursing mothers.
Storage
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Clinical monograph: tetramisole
BNF-referencedTetramisole is a broad-spectrum anthelmintic agent primarily used in veterinary medicine, but it has also been utilized in human medicine for the treatment of certain parasitic infections. It is effective against a range of nematodes and has been noted for its immunomodulatory effects, which may contribute to its antiparasitic activity.
Indications
- Nematode infections
- Ascariasis
- Hookworm infections
- Strongyloidiasis
Dosage
Children: Refer to BNF for Children for specific dosing recommendations.
Adults: Refer to BNF for specific dosing recommendations.
Mechanism of action
Tetramisole causes a rapid and sustained muscle paralysis in parasitic worms.
Pharmacodynamics
Tetramisole acts as a nicotinic agonist at the neuromuscular junction of nematodes, leading to paralysis. This paralysis is a result of prolonged depolarization of the muscle membrane, which prevents the worm from maintaining its position within the host and allows for its expulsion. The drug is effective against various gastrointestinal worms, making it useful in treating infections caused by these parasites.
Pharmacokinetics
Tetramisole is rapidly absorbed after oral administration, with peak plasma concentrations occurring within a few hours. It undergoes hepatic metabolism, and its metabolites are primarily excreted in the urine. The elimination half-life is variable, depending on the formulation and individual patient factors, but it is generally in the range of hours.
Pregnancy
Tetramisole should only be used if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
Tetramisole is excreted in breast milk. Caution should be exercised when administering to nursing mothers.
Storage
Store in a cool, dry place away from light.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: tetramisole
PubChem CID 3913Molecular formula: C11H12N2S
Mechanism of action
Tetramisole causes a rapid and sustained muscle paralysis in parasitic worms.
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.