Redmond Eye Drops
Predinisolone Acetate 10 mg
What it does
Prednisolone is a steroid medication that helps reduce inflammation and suppress the immune system.
Commonly used for: inflammatory conditions (like arthritis), allergic reactions (like asthma), autoimmune diseases (like lupus), skin conditions (like eczema)
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Sourcing - Kenya onlyRegistration & product details
Source: Zambia Medicines Regulatory Authority · fetched 2026-03-12 00:01:24 · updated 2026-09-14 03:32:58
About this medicine
Prednisolone is a steroid medication that helps reduce inflammation and suppress the immune system.
What it treats
- inflammatory conditions (like arthritis)
- allergic reactions (like asthma)
- autoimmune diseases (like lupus)
- skin conditions (like eczema)
How it works
It works by decreasing inflammation and reducing the body's immune response.
Who it's for
It is used for people with conditions that cause inflammation or require immune system suppression.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: predinisolone
Prednisolone is a synthetic glucocorticoid that mimics the effects of cortisol, a natural steroid hormone produced by the adrenal glands. It is widely used for its potent anti-inflammatory and immunosuppressive properties. Prednisolone is effective in treating a variety of conditions, including autoimmune diseases, allergic reactions, and inflammatory disorders.
Indications
- Asthma
- Chronic obstructive pulmonary disease (COPD)
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Dermatological conditions (e.g., eczema, psoriasis)
- Allergic reactions
- Inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis)
- Certain cancers (e.g., leukemia, lymphoma)
Dosage
Children: Refer to the BNF for Children for appropriate dosing information in children.
Adults: Refer to the BNF for specific dosing guidelines based on condition and severity.
Mechanism of action
Prednisolone exerts its effects by binding to the glucocorticoid receptor in the cytoplasm, which then translocates to the nucleus. This complex interacts with glucocorticoid response elements in the DNA, leading to the modulation of gene expression. This results in decreased production of pro-inflammatory cytokines, inhibition of immune cell proliferation, and suppression of the inflammatory response.
Pharmacodynamics
Prednisolone demonstrates anti-inflammatory effects by reducing the infiltration of inflammatory cells and inhibiting the release of inflammatory mediators such as prostaglandins and leukotrienes. Its immunosuppressive actions are characterized by the inhibition of T-cell activation and the reduction of antibody production. The drug's effects are dose-dependent and can lead to both therapeutic benefits and potential adverse effects.
Pharmacokinetics
Prednisolone is well absorbed following oral administration, with peak plasma concentrations typically occurring within 1-2 hours. It is extensively metabolized in the liver, primarily by the cytochrome P450 enzyme system, producing active and inactive metabolites. The elimination half-life is approximately 2-3 hours, and the drug is primarily excreted in urine. Factors such as liver function and concurrent medications can affect its metabolism and clearance.
Contra-indications
- Systemic fungal infections
- Hypersensitivity to prednisolone or any of its components
- Live vaccines in immunocompromised patients
Adverse effects
- Increased susceptibility to infections
- Gastrointestinal disturbances
- Weight gain and fluid retention
- Hypertension
- Hyperglycemia
- Osteoporosis
- Mood changes and psychiatric disturbances
- Cushing's syndrome with prolonged use
Interactions
- Non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal side effects
- Anticoagulants may have altered effects
- Diuretics may enhance potassium loss
- Vaccines may be less effective in immunosuppressed patients
Precautions
- Use with caution in patients with diabetes mellitus
- Monitor for signs of infection
- Gradual withdrawal is recommended after long-term therapy to avoid adrenal insufficiency
- Use with caution in patients with a history of peptic ulcer disease
Pregnancy
Prednisolone can be used during pregnancy if the benefits outweigh the risks. It is classified as Category C.
Breast-feeding
Prednisolone is excreted in breast milk, and caution is advised when administering to nursing mothers.
Storage
Store at room temperature, away from moisture and heat. Protect from light.
Formulations
- Tablets
- Oral solution
- Injection (intravenous and intramuscular)
- Topical formulations (creams and ointments)
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.