S-AMLO 5
S-AMLODIPINE BESILIATE
What it does
Besilate is a medication used to treat various conditions, although specific details about its uses are not provided.
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 20:02:26 · updated 2026-08-03 03:11:48
About this medicine
Besilate is a medication used to treat various conditions, although specific details about its uses are not provided.
How it works
The exact mechanism of how besilate works is not specified, but it is intended to help manage certain health issues.
Who it's for
Besilate may be prescribed for adults and children depending on their specific health conditions.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: besiliate
Besilate is a medication primarily used as an antihypertensive agent. It belongs to the class of calcium channel blockers and is utilized in the management of hypertension and certain cardiovascular conditions. The drug functions by relaxing blood vessels, which helps to lower blood pressure and improve blood flow.
Indications
- Hypertension
- Angina pectoris
- Certain types of arrhythmias
Dosage
Children: Refer to the BNF for Children for appropriate dosing guidelines in pediatric patients.
Adults: Refer to appropriate clinical guidelines for specific dosing information, as it can vary based on individual patient factors and clinical conditions.
Mechanism of action
Besilate works by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac muscle. This inhibition leads to vasodilation and decreased contractility of the heart, resulting in lowered blood pressure and reduced cardiac workload. The specific pathways involve the blockade of calcium entry during depolarization, which is crucial for muscle contraction.
Pharmacodynamics
The pharmacodynamic profile of besilate indicates that it effectively reduces systemic vascular resistance and lowers blood pressure. Its effects on heart rate and cardiac output may vary depending on the specific clinical scenario, but overall, it is characterized by a reduction in the workload on the heart and improved oxygen delivery to tissues.
Pharmacokinetics
Besilate is usually well-absorbed following oral administration, with peak plasma concentrations typically occurring within a few hours. The drug is metabolized in the liver, primarily through cytochrome P450 enzymes, and has a variable half-life that can influence dosing intervals. Excretion occurs mainly via the kidneys, with both unchanged drug and metabolites being eliminated in urine.
Pregnancy
Consult healthcare professional before use. Limited data on safety.
Breast-feeding
Consult healthcare professional before use. Limited data on excretion in breast milk.
Storage
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.