SANIDEX 2% W/V LIQUID

Indications

• Warts, particularly plantar warts
• Condylomata acuminata affecting the penis or female external genitalia
• Sterilization of medical instruments

Dosage

Children: For children aged 2–17 years (initiated under specialist supervision), apply twice daily for 3 consecutive days. Treatment may be repeated at weekly intervals if necessary for a total of four 3-day courses.

Adults: Apply twice daily to the lesion for up to 3 applications, ensuring to remove dead skin before use. Treatment may be repeated weekly if necessary.

Mechanism of action

Glutaraldehyde functions primarily by cross-linking with proteins and nucleic acids, leading to microbial cell death. This cross-linking interferes with the normal functioning of cellular components, thereby disrupting metabolism and replication in bacteria, viruses, and fungi.

Pharmacodynamics

The pharmacodynamic profile of glutaraldehyde is characterized by its rapid action as a broad-spectrum antimicrobial agent. It exhibits bactericidal, virucidal, and fungicidal properties, making it effective against a wide range of pathogens, including resistant strains. Its activity is influenced by concentration, exposure time, and pH levels, with higher concentrations and longer exposure times enhancing its antimicrobial effects.

Pharmacokinetics

Glutaraldehyde is primarily used topically and does not have significant systemic absorption when applied appropriately. It is rapidly metabolized and eliminated from the body. The exact pharmacokinetic parameters, such as half-life or volume of distribution, are not well characterized due to its topical use and rapid inactivation upon contact with tissues.

Contra-indications

• Not for application to anogenital areas
• Not for application to the face
• Not for application to mucosa
• Avoid broken skin

Adverse effects

• Skin irritation
• Rash
• Balanoposthitis
• Severe cutaneous adverse reactions
• Argyria
• Methaemoglobinaemia

Precautions

• Avoid application to normal skin
• Avoid open wounds
• Keep away from eyes
• Use under specialist supervision for children

Pregnancy

Avoid use during pregnancy.

Breast-feeding

Avoid use during breastfeeding.

Storage

Store in a cool, dry place, away from direct sunlight.

Formulations

• Warticon 0.5% solution
• Glutaraldehyde liquid