What it does
Sennoside is a natural laxative that helps relieve constipation by stimulating bowel movements.
Commonly used for: constipation, irregular bowel movements
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Sourcing - Kenya onlyRegistration & product details
Source: Zambia Medicines Regulatory Authority · fetched 2026-03-11 23:59:46 · updated 2026-09-28 03:30:49
About this medicine
Sennoside is a natural laxative that helps relieve constipation by stimulating bowel movements.
What it treats
- constipation
- irregular bowel movements
How it works
Sennoside works by increasing the movement in the intestines, which helps to push stool through more easily.
Who it's for
It is suitable for adults and children over a certain age who are experiencing constipation.
Cautions
- • Do not use if you have a blockage in your intestines.
- • Consult a healthcare provider if you have ongoing bowel problems.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: sennoside
BNF-referencedSennosides are a group of natural compounds derived from the senna plant, primarily used as stimulant laxatives. They are commonly used to treat constipation and to prepare patients for certain medical procedures. Sennosides work by stimulating intestinal motility, leading to increased bowel movement. They are typically well-tolerated and can be used in various populations, including children and the elderly.
Indications
- Constipation
- Preparation for diagnostic procedures
- Bowel cleansing prior to surgery
Dosage
Children: For children aged 2 to 6 years, the typical dose is 2.5 to 5 mg orally, while for children aged 6 to 12 years, the dose can be increased to 5 to 10 mg orally. Always refer to the BNF for Children for precise dosing.
Adults: The usual adult dose is 7.5 to 15 mg of sennosides taken orally once daily, which may be adjusted based on individual response and clinical need.
Mechanism of action
Sennosides exert their laxative effect through direct stimulation of the mucosal nerve plexus in the colon. This action promotes increased peristalsis and enhances water and electrolyte secretion into the intestinal lumen. As a result, the stool becomes softer and easier to pass, facilitating bowel movements.
Pharmacodynamics
The pharmacodynamics of sennosides involve their ability to increase colonic motility and alter electrolyte transport in the intestines. This leads to an increase in the bulk and water content of the stool, effectively reducing transit time. The onset of action typically occurs within 6 to 12 hours after oral administration, making them suitable for overnight relief of constipation.
Pharmacokinetics
Sennosides are not absorbed significantly in the gastrointestinal tract. They are metabolized by intestinal bacteria into active metabolites, which are responsible for the laxative effect. The elimination of these metabolites occurs primarily through feces. Due to their minimal systemic absorption, sennosides have a low potential for systemic side effects.
Adverse effects
- Abdominal cramps
- Diarrhea
- Nausea
- Electrolyte imbalance
- Dehydration
Precautions
- Use with caution in patients with intestinal obstruction or severe dehydration
- Prolonged use may lead to dependence
- Monitor electrolyte levels in long-term use
Pregnancy
Sennosides should be used with caution during pregnancy. Consult a healthcare provider before use.
Breast-feeding
Sennosides are excreted in breast milk. Consult a healthcare provider before use.
Storage
Store in a cool, dry place, protected from light.
Formulations
- Tablets
- Liquid preparations
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: sennoside
PubChem CID 656822Molecular formula: C42H38O20
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.