SINUMAX ALLERGY NASAL SPRAY

Indications

• Allergic rhinitis
• Allergic conjunctivitis
• Other allergic conditions

Dosage

Children: Refer to the BNF for Children for appropriate dosing guidelines for paediatric patients.

Adults: Refer to the BNF for appropriate dosing guidelines for adults.

Mechanism of action

Levocabastine functions as an antagonist of the H1 histamine receptor. By binding to these receptors, it inhibits the physiological effects of histamine, which is responsible for various allergic symptoms. This mechanism effectively reduces vasodilation, increased vascular permeability, and sensory nerve stimulation associated with allergic responses.

Pharmacodynamics

The pharmacodynamics of levocabastine are characterized by its competitive inhibition of histamine at H1 receptors, leading to decreased vascular permeability and reduced secretion of mucus. Additionally, it may exert mild sedative effects, though it is less sedating than first-generation antihistamines due to its selectivity for peripheral H1 receptors.

Pharmacokinetics

Levocabastine is well-absorbed following topical administration, with a rapid onset of action. The drug exhibits a half-life that supports frequent dosing. It is widely distributed in the body and undergoes hepatic metabolism, with elimination primarily via renal pathways. The pharmacokinetics may vary based on the formulation used and the route of administration.

Adverse effects

• Drowsiness
• Dry mouth
• Nausea
• Headache
• Dizziness

Precautions

• Use with caution in patients with glaucoma
• Caution in patients with urinary retention

Pregnancy

There is limited data on the use of levocabastine in pregnancy. It should only be used if the potential benefit justifies the potential risk to the fetus.

Breast-feeding

Levocabastine is excreted in breast milk. Caution should be exercised when administering to breastfeeding women.

Storage

Store in a cool, dry place away from light. Keep out of reach of children.

Formulations

• Ophthalmic solution
• Nasal spray