What it does
Hyoscin-butyl is a medication used to relieve stomach and bowel cramps.
Commonly used for: stomach cramps, irritable bowel syndrome (IBS), spasms of the digestive tract
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 21:20:28 · updated 2026-07-20 09:03:43
About this medicine
Hyoscin-butyl is a medication used to relieve stomach and bowel cramps.
What it treats
- stomach cramps
- irritable bowel syndrome (IBS)
- spasms of the digestive tract
How it works
It works by relaxing the muscles in the stomach and intestines, which helps reduce pain and discomfort.
Who it's for
This medicine is for adults and children who experience painful cramps in their stomach or intestines.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: hyoscinbutyl
Hyoscinbutyl is an antimuscarinic agent primarily used to relieve smooth muscle spasms in the gastrointestinal and genitourinary tracts. It is derived from scopolamine and acts by antagonizing the action of acetylcholine at muscarinic receptors, leading to reduced motility and secretions.
Indications
- Abdominal cramps
- Irritable bowel syndrome
- Renal colic
- Biliary colic
- Spasmodic dysmenorrhea
Dosage
Children: Paediatric dosing should be referenced from the BNF for Children, as it varies based on age, weight, and condition being treated.
Adults: For adults, dosing should be determined based on clinical guidelines, typically starting with a low dose and titrating as needed. Refer to established guidelines for specific dosing information.
Mechanism of action
Hyoscinbutyl selectively inhibits the muscarinic acetylcholine receptors, particularly M1 and M3 subtypes, which are prevalent in smooth muscle. This blockade results in decreased contraction of smooth muscle tissues in the gastrointestinal and urinary systems, thus alleviating spasms and associated pain.
Pharmacodynamics
The drug exhibits a dose-dependent effect on smooth muscle, with higher doses leading to more pronounced antispasmodic effects. It also reduces glandular secretions, which can aid in situations where excessive secretions may complicate clinical conditions. The onset of action is generally rapid, with effects lasting several hours, depending on the route of administration.
Pharmacokinetics
Hyoscinbutyl is well-absorbed after oral administration, with peak plasma concentrations reached within 1 to 2 hours. It undergoes hepatic metabolism, and its elimination half-life ranges from approximately 4 to 10 hours. The drug is excreted mainly in the urine, with a small portion eliminated as unchanged drug.
Contra-indications
- Myasthenia gravis
- Glaucoma
- Prostatic hypertrophy
- Pyloric stenosis
- Intestinal obstruction
- Tachycardia
Adverse effects
- Dry mouth
- Blurred vision
- Constipation
- Dizziness
- Nausea
- Urinary retention
Interactions
- Anticholinergic drugs
- Tricyclic antidepressants
- Antihistamines
- Muscle relaxants
Precautions
- Use with caution in patients with cardiovascular disease
- May impair ability to drive or operate machinery
- Use with caution in elderly patients
Pregnancy
Hyoscine butylbromide should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult a healthcare professional before use.
Breast-feeding
Hyoscine butylbromide is excreted in breast milk, caution is advised when administering to nursing mothers.
Storage
Store at room temperature, away from moisture and heat. Keep out of reach of children.
Formulations
- Tablets
- Injectable solution
- Oral solution
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.