SUPRAPROCT SUPPOSITORIES
TRIBENOSIDELIDOCAINE HCL
What it does
Tribenoside and lidocaine is a combination medication used to relieve pain and discomfort in certain conditions.
Commonly used for: pain relief (analgesia), varicose veins, hemorrhoids
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 21:01:59 · updated 2026-07-26 13:44:19
About this medicine
Tribenoside and lidocaine is a combination medication used to relieve pain and discomfort in certain conditions.
What it treats
- pain relief (analgesia)
- varicose veins
- hemorrhoids
How it works
Tribenoside helps improve blood flow and reduce swelling, while lidocaine numbs the area to decrease pain.
Who it's for
This medication is for adults experiencing pain or discomfort from conditions like varicose veins and hemorrhoids.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: tribenosidelidocaine
Tribenoside-lidocaine is a combination medication that combines the venotonic agent tribenoside, which is used to treat venous insufficiency, and lidocaine, a local anesthetic. This combination is employed primarily for its properties in alleviating symptoms associated with hemorrhoids, anal fissures, and other conditions involving pain and inflammation in the anorectal area.
Indications
- Hemorrhoids
- Anal fissures
- Anorectal pain
- Venous insufficiency symptoms
Dosage
Children: Refer to the BNF for Children for specific dosing information based on the condition being treated.
Adults: Refer to the BNF for specific dosing information based on the condition being treated.
Mechanism of action
Tribenoside acts by reducing capillary permeability and increasing venous tone, which helps to alleviate symptoms associated with venous insufficiency. Lidocaine works by blocking sodium channels, leading to a temporary loss of sensation in the area where it is applied, thus providing local analgesia.
Pharmacodynamics
The combination of tribenoside and lidocaine provides both symptomatic relief from pain and discomfort while also addressing underlying venous issues. Tribenoside enhances venous return and reduces edema, while lidocaine provides immediate pain relief, making it effective in treating conditions that involve both pain and venous dysfunction.
Pharmacokinetics
After topical application, lidocaine is rapidly absorbed into the systemic circulation, with peak plasma concentrations occurring within 30 minutes to 2 hours. It is metabolized primarily in the liver via cytochrome P450 enzymes. Tribenoside, being a poorly absorbed drug when taken orally, acts locally at the site of application with minimal systemic absorption. The elimination half-life of lidocaine varies between individuals but is generally around 1.5 to 2 hours.
Contra-indications
- Hypersensitivity to lidocaine or any other local anesthetics
- Severe heart block
- Atrioventricular block without a pacemaker
- Porphyria
Adverse effects
- Hypotension
- Bradycardia
- Dizziness
- Tinnitus
- Nausea
- Allergic reactions
- Seizures
- Respiratory depression
Interactions
- Caution with other antiarrhythmics
- Increased risk of toxicity with CYP3A4 inhibitors
- Potentially increased effects with beta-blockers
- Increased risk of CNS toxicity with other central nervous system depressants
Precautions
- Use with caution in patients with hepatic impairment
- Careful monitoring in elderly patients
- Caution in patients with cardiovascular disease
- Avoid in patients with history of seizures
Pregnancy
Use only if clearly needed, as lidocaine crosses the placenta. Consult with healthcare provider.
Breast-feeding
Lidocaine is excreted in breast milk; use caution and assess risk versus benefit.
Storage
Store at room temperature, away from light and moisture. Keep out of reach of children.
Formulations
- Topical gel
- Injectable solution
- Transdermal patch
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.