SYBRAVA SOLUTION FOR INJECTION
INCLISIRAN
What it does
Inclisiran is a medication used to lower cholesterol levels in the blood.
Commonly used for: high cholesterol (hyperlipidemia), familial hypercholesterolemia
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 19:42:45 · updated 2026-10-20 02:20:21
About this medicine
Inclisiran is a medication used to lower cholesterol levels in the blood.
What it treats
- high cholesterol (hyperlipidemia)
- familial hypercholesterolemia
How it works
Inclisiran helps the body reduce the amount of cholesterol produced in the liver.
Who it's for
This medication is for adults who have high cholesterol levels and need additional help to manage it.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: Inclisiran
BNF-referencedInclisiran is a small interfering RNA that targets and inhibits the production of proprotein convertase subtilisin/kexin type 9 (PCSK9). By reducing PCSK9 levels, Inclisiran enhances the ability of the liver to clear low-density lipoprotein (LDL) cholesterol from the bloodstream, thereby effectively lowering LDL cholesterol levels. It is administered via subcutaneous injection and is used primarily in the management of hyperlipidaemia, particularly in patients with familial hypercholesterolaemia.
Indications
- Primary hypercholesterolaemia
- Mixed dyslipidaemia
- Homozygous familial hypercholesterolaemia
Dosage
Children: null
Adults: 420 mg every 2 weeks, or for specific cases, 284 mg initially for 1 dose, followed by 284 mg after 3 months for 1 dose, then 284 mg every 6 months.
Mechanism of action
Inclisiran acts by interfering with the messenger RNA (mRNA) for PCSK9, leading to a decrease in PCSK9 protein production. This action results in increased uptake of LDL cholesterol by the liver and a reduction in circulating LDL cholesterol levels. The inhibition of PCSK9 enhances the recycling of LDL receptors, which further contributes to lowering LDL cholesterol in the bloodstream.
Pharmacodynamics
The pharmacodynamic effects of Inclisiran include significant reductions in LDL cholesterol levels, observed within weeks of administration. The drug's effects are sustained over time, with maintenance doses leading to persistent reductions in LDL cholesterol. The efficacy of Inclisiran can be seen in various patient populations, including those with familial hypercholesterolaemia and those at high cardiovascular risk.
Pharmacokinetics
Inclisiran is administered subcutaneously, with peak plasma concentrations occurring approximately 2 to 4 hours post-injection. It has a long half-life, allowing for less frequent dosing. The drug is primarily eliminated by the liver, with renal excretion playing a minimal role in its pharmacokinetics. The pharmacokinetic profile is not significantly altered in patients with liver or renal impairment, but caution is advised in severe cases.
Contra-indications
- Hypersensitivity to inclisiran or any excipients
- Severe hepatic impairment
- Severe renal impairment
Adverse effects
- Arthralgia
- Back pain
- Increased risk of infection
- Nausea
- Skin reactions
- Influenza-like illness
- Angioedema
Precautions
- Caution in patients with moderate hepatic impairment
- Caution in patients with moderate to severe renal impairment
- Patients should be trained in subcutaneous injection technique
Pregnancy
Avoid unless potential benefit outweighs risk-limited information available.
Breast-feeding
Avoid-present in milk in animal studies.
Storage
Store in a refrigerator (2–8°C)-consult product literature for further information regarding storage outside refrigerator.
Formulations
- Solution for injection
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.