SYLENT 125MG INJECTION
ETHAMSYLATE
What it does
Ethamsylate is a medication used to help control bleeding and promote normal blood clotting.
Commonly used for: bleeding disorders, heavy menstrual periods (menorrhagia), surgery-related bleeding
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 21:02:55 · updated 2026-07-26 13:45:15
About this medicine
Ethamsylate is a medication used to help control bleeding and promote normal blood clotting.
What it treats
- bleeding disorders
- heavy menstrual periods (menorrhagia)
- surgery-related bleeding
How it works
It helps stabilize blood vessels and reduces excessive bleeding.
Who it's for
This medication is for people who are experiencing abnormal bleeding.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: ethamsylate
BNF-referencedEthamsylate is a medication primarily used to manage bleeding disorders, particularly in situations where there is a need to stabilize capillary integrity. It is often used in obstetrics and gynecology to control menorrhagia and to prevent bleeding during surgery. Ethamsylate enhances platelet aggregation and stabilizes blood vessels, making it effective in reducing blood loss.
Indications
- Menorrhagia
- Preventing bleeding in surgical procedures
- Capillary fragility
- Bleeding disorders
Dosage
Children: For paediatric patients, refer to the BNF for Children for appropriate dosing recommendations.
Adults: The usual adult dosage for ethamsylate is 500 mg taken three times daily, adjusted according to the severity of the condition and clinical response. Maximum doses may vary based on clinical guidelines.
Mechanism of action
Ethamsylate works by promoting the stability of capillary membranes and enhancing the aggregation of platelets. It is thought to inhibit the release of certain substances from platelets that can lead to vasodilation and increased permeability of blood vessels, thus reducing bleeding.
Pharmacodynamics
Ethamsylate exhibits hemostatic properties by acting on the microcirculation, helping to prevent excessive blood loss. It does not affect the coagulation factors or the platelet count but enhances the clotting process by acting on the vascular endothelial cells and platelets.
Pharmacokinetics
Ethamsylate is well absorbed after oral administration, with peak plasma concentrations occurring within 1 to 2 hours. It is metabolized in the liver and excreted primarily through the kidneys. The half-life of ethamsylate is approximately 2 to 4 hours. It is important to monitor renal function in patients receiving ethamsylate, as renal impairment may affect its clearance.
Contra-indications
- Hypersensitivity to ethamsylate or any component of the formulation
- Active or history of thrombosis
- Severe renal impairment
Adverse effects
- Nausea
- Vomiting
- Diarrhea
- Headache
- Dizziness
- Rash
- Urticaria
- Hypotension
Interactions
- Concurrent use with anticoagulants may increase the risk of thrombosis
- Caution with other medications that may affect coagulation
Precautions
- Use with caution in patients with a history of thromboembolic events
- Monitor renal function in patients with renal impairment
- Caution in patients with a history of allergic reactions
Pregnancy
Ethamsylate should be used in pregnancy only if clearly needed, after assessing the benefits against risks.
Breast-feeding
Ethamsylate is excreted in breast milk; caution is advised when administered to breastfeeding women.
Storage
Store in a cool, dry place, protected from light. Keep out of reach of children.
Formulations
- Tablets
- Injectable solution
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.
Molecular reference: ethamsylate
PubChem CID 17506Molecular formula: C6H6O5S.C4H11N
Source: PubChem (NCBI) · pathways from PathBank, Reactome, WikiPathways & PharmGKB.
This drug in other countries
The same active ingredient registered across other registries we cover - including different brands.