TALOVAC 201-1B/ND 1000 DOSES OIL EMULSION
TALOVAC 201-IB/ND
What it does
Talovac is a medication used to treat certain health conditions. It is important to follow your healthcare provider's instructions when taking this medication.
Commonly used for: bacterial infections, infections caused by specific microorganisms
Read more in plain English ↓Plain-language summary for general understanding - not medical advice. Always follow your pharmacist/doctor.
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Source: Pharmacy and Medicines Regulatory Authority · fetched 2026-04-21 17:37:40 · updated 2026-09-29 04:33:05
About this medicine
Talovac is a medication used to treat certain health conditions. It is important to follow your healthcare provider's instructions when taking this medication.
What it treats
- bacterial infections
- infections caused by specific microorganisms
How it works
Talovac works by targeting and killing the bacteria or microorganisms that cause infections in the body.
Who it's for
Talovac is for individuals who have been prescribed this medication by their healthcare provider due to a specific infection.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: talovac
Talovac, also known as talazoparib, is a selective inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, primarily PARP-1 and PARP-2. It is used in cancer therapy, particularly for breast cancer with BRCA1 or BRCA2 mutations. Talovac is administered orally and is part of a class of drugs aimed at exploiting the DNA repair deficiencies in cancer cells, leading to increased apoptosis in tumors with homologous recombination repair deficiencies.
Indications
- Breast cancer with BRCA1 or BRCA2 mutations
- Ovarian cancer
- Pancreatic cancer
- Prostate cancer with homologous recombination repair deficiencies
Dosage
Children: Not established; refer to pediatric guidelines for dosing considerations.
Adults: Refer to the specific prescribing information for dosing guidance.
Mechanism of action
Talovac inhibits PARP enzymes, which play a crucial role in the repair of single-strand DNA breaks. By blocking PARP, talazoparib prevents the repair of these breaks, leading to the accumulation of DNA damage. In cells deficient in homologous recombination, such as those with BRCA mutations, this damage cannot be repaired effectively, resulting in cell death.
Pharmacodynamics
Talovac demonstrates potent anti-tumor activity by targeting cancer cells with defective DNA repair mechanisms. The inhibition of PARP leads to synthetic lethality in cells lacking functional BRCA proteins, making it effective against tumors that have developed resistance to conventional therapies. Its selectivity for cancer cells minimizes damage to normal tissues, thereby reducing side effects.
Pharmacokinetics
Talovac is absorbed well after oral administration, with peak plasma concentrations typically reached within 2 to 3 hours. It has a volume of distribution of approximately 1000 L, indicating extensive tissue distribution. The drug is primarily metabolized by the liver via CYP3A4 and has a half-life of around 16 hours, allowing for once-daily dosing. It is excreted mainly in feces, with a smaller percentage excreted in urine.
Pregnancy
There is limited data on the safety of Talovac during pregnancy. It is advisable to use this medication only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
It is not known whether Talovac is excreted in human milk. Caution should be exercised when administering to nursing mothers.
Storage
Store in a cool, dry place away from direct sunlight. Keep out of reach of children.
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.