TERIZIDONE MACLEODS 250 mg CAPSULES

Indications

• Tuberculosis
• Resistant tuberculosis
• Pulmonary tuberculosis
• Extrapulmonary tuberculosis

Dosage

Children: Refer to BNF for Children for specific dosing recommendations, as pediatric dosing must be determined carefully based on weight and age.

Adults: Refer to BNF for specific dosing guidelines, typically adjusted based on the severity of the condition and renal function.

Mechanism of action

Terizidone acts by inhibiting the synthesis of mycolic acids in the bacterial cell wall of Mycobacterium tuberculosis. This disruption in the cell wall integrity leads to cell lysis and ultimately results in the death of the bacteria. It is thought to have a dual mechanism that involves both inhibition of cell wall synthesis and interference with nucleic acid synthesis.

Pharmacodynamics

Terizidone exhibits bactericidal activity against actively replicating Mycobacterium tuberculosis. Its effectiveness is enhanced in combination with other antitubercular agents, making it suitable for multi-drug resistant tuberculosis. The drug's pharmacodynamic profile indicates that it has a prolonged post-antibiotic effect, which may contribute to its efficacy in treating tuberculosis.

Pharmacokinetics

After oral administration, terizidone is well absorbed and reaches peak plasma concentrations within 1 to 2 hours. It has a half-life of approximately 4 to 8 hours, allowing for once or twice daily dosing. Terizidone is metabolized primarily in the liver and excreted mostly in the urine, with a small percentage eliminated in feces. It is important to monitor renal function, as dose adjustments may be necessary in patients with renal impairment.

Contra-indications

• Hypersensitivity to terizidone or any of its components.
• Severe renal impairment.

Adverse effects

• Dizziness
• Nausea
• Fatigue
• Headache
• Somnolence
• Rash
• Hypersensitivity reactions
• Elevation of liver enzymes

Interactions

• May interact with other CNS depressants, increasing sedation.
• Caution when used with drugs that affect renal function.

Precautions

• Use with caution in patients with a history of seizures or psychiatric disorders.
• Monitor liver function tests periodically during treatment.

Pregnancy

Terizidone should only be used in pregnancy if the potential benefit justifies the potential risk to the fetus. Limited data on use during pregnancy.

Breast-feeding

It is not known whether terizidone is excreted in human milk. Caution should be exercised when administering to nursing mothers.

Storage

Store at room temperature, away from moisture and heat. Keep out of reach of children.

Formulations

• Tablets