TIMENTIN INJECTION

Indications

• Bacterial infections
• Pneumonia
• Urinary tract infections
• Skin and soft tissue infections
• Intra-abdominal infections
• Sepsis

Dosage

Children: Refer to the BNF for Children for paediatric dosing recommendations.

Adults: Refer to the BNF for specific dosing guidelines.

Mechanism of action

Ticarcillin's principal mechanism of action revolves around its capacity to prevent the cross-linking of peptidoglycan during bacterial cell wall synthesis. Consequently, when the offending bacteria attempt to undergo cell division, cell death occurs.

Pharmacodynamics

Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. Ticarcillin is, however, susceptible to degradation by ß-lactamases, and therefore, the spectrum of activity does not normally include organisms which produce these enzymes.

Pharmacokinetics

Ticarcillin is typically administered parenterally and exhibits a rapid distribution in body tissues. It is primarily excreted unchanged in the urine. The pharmacokinetics can be influenced by renal function, necessitating dosage adjustments in patients with impaired kidney function.

Pregnancy

Ticarcillin is classified as a pregnancy category B drug. Animal studies have not demonstrated a risk to the fetus, but there are no adequate and well-controlled studies in pregnant women.

Breast-feeding

Ticarcillin is excreted in human milk. Caution should be exercised when administering to nursing mothers, as potential effects on the infant are unknown.

Storage

Store below 25°C. Protect from light. Reconstituted solutions should be used promptly or stored at 2-8°C and used within 24 hours.

Formulations

• Ticarcillin disodium

Mechanism of action

Ticarcillin's principal mechanism of action revolves around its capacity to prevent the cross-linking of peptidoglycan during bacterial cell wall synthesis. Consequently, when the offending bacteria attempt to undergo cell division, cell death occurs.

Pharmacodynamics

Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. Ticarcillin is, however, susceptible to degradation by ß-lactamases, and therefore, the spectrum of activity does not normally include organisms which produce these enzymes.