What it does
Travoprost is a medicine used to lower eye pressure in people with certain eye conditions.
Commonly used for: glaucoma, ocular hypertension
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Source: Pharmacy and Poisons Board · fetched 2026-01-28 21:59:42 · updated 2026-03-23 04:44:50
About this medicine
Travoprost is a medicine used to lower eye pressure in people with certain eye conditions.
What it treats
- glaucoma
- ocular hypertension
How it works
Travoprost helps to increase the drainage of fluid from the eye, which reduces eye pressure.
Who it's for
This medication is for adults and children over the age of 2 who have increased eye pressure.
Cautions
- • May cause eye redness or darkening of eyelashes.
- • Avoid contact with the skin and wash hands after use.
AI-assisted summary grounded in BNF data - general information only, not medical advice. Always confirm with your pharmacist or doctor.
Clinical monograph: travopost
Travoprost is a synthetic prostaglandin analog used primarily in the management of elevated intraocular pressure in patients with open-angle glaucoma and ocular hypertension. It functions by increasing the outflow of aqueous humor, thereby reducing intraocular pressure. Travoprost is typically administered as an ophthalmic solution.
Indications
- Open-angle glaucoma
- Ocular hypertension
Dosage
Children: Refer to the BNF for Children for appropriate dosing information.
Adults: The usual recommended dose is one drop in the affected eye(s) once daily in the evening.
Mechanism of action
Travoprost is a selective agonist of the prostaglandin FP receptor. Upon binding to these receptors in the ciliary body and trabecular meshwork, it enhances the uveoscleral outflow of aqueous humor, leading to a decrease in intraocular pressure.
Pharmacodynamics
The pharmacodynamic effects of travoprost involve its ability to lower intraocular pressure by increasing the drainage of aqueous humor through both the trabecular and uveoscleral pathways. The onset of action typically occurs within 2 hours after administration, with maximum effect reached at approximately 12 hours. The duration of action can last for up to 24 hours.
Pharmacokinetics
Travoprost is rapidly hydrolyzed to its active form after instillation into the eye. The peak concentration of the active metabolite in the aqueous humor occurs within 1 to 2 hours. The systemic absorption is minimal, with less than 1% of the dose entering the systemic circulation. The elimination half-life of travoprost is approximately 20 minutes in the aqueous humor, with systemic clearance primarily via hepatic metabolism.
Contra-indications
- Hypersensitivity to travoprost or any of its components
- Active intraocular inflammation
- History of herpetic keratitis
Adverse effects
- Ocular hyperemia
- Iris pigmentation changes
- Eyelash changes
- Dry eye
- Burning or stinging sensation in the eye
- Conjunctival hyperemia
- Eyelid margin crusting
Interactions
- Other ophthalmic agents should be administered at least 5 minutes apart
- Systemic absorption may lead to interactions with other medications affecting ocular pressure
Precautions
- Use with caution in patients with a history of asthma or other respiratory conditions
- Monitor intraocular pressure regularly
- Use with caution in patients with a history of ocular infections
Pregnancy
There are no adequate and well-controlled studies in pregnant women. Use only if the potential benefit justifies the potential risk to the fetus.
Breast-feeding
It is not known whether travoprost is excreted in human milk. Caution should be exercised when administered to a nursing woman.
Storage
Store at 2-8 degrees Celsius. Do not freeze. Keep out of reach of children. Discard any unused solution after 28 days.
Formulations
- Ophthalmic solution 0.004%
AI-synthesized from BNF references - general information only, not a substitute for professional medical advice or the current BNF. Verify doses with a pharmacist.